Proteome and Phosphoproteome Turnover Atlas in Mice – Paper Published In Cell Journal with 45.5 IF
Dr Abhijit Dasgupta, Assistant Professor from the Department of Computer Science and Engineering, has published his breakthrough research article titled “Turnover Atlas of Proteome and Phosphoproteome Across Mouse Tissues and Brain Regions” in the nature index journal Cell having an impact factor of 45.5.
Abstract
This study presents a comprehensive in vivo atlas of protein and phosphoprotein turnover across 16 mouse tissues and brain regions, integrating advanced mass spectrometry with stable isotope labeling. By mapping over 11,000 proteins and 40,000 phosphosites, the study reveals tissue-specific patterns of protein lifetimes, correlating them with abundance, function, and protein-protein interactions (PPI). It highlights how phosphorylation regulates protein stability and how turnover is linked to peroxisome function, ubiquitination, and neurodegeneration-associated proteins such as Tau and α-synuclein. This high-resolution resource enhances our understanding of proteostasis and dynamic protein regulation, providing new insights into tissue-specific physiology and disease mechanisms.
Explanation of the Research in Layperson’s Terms
All cells in the body continuously make and break down proteins. The balance of these processes—called protein turnover—is vital for keeping tissues healthy. But until now, scientists didn’t have a clear, detailed map of how protein turnover works across different tissues and brain regions.
In this study, researchers used advanced techniques to measure how long thousands of proteins and their phosphorylated (chemically modified) versions last in 16 parts of the mouse body. They discovered that some proteins, especially in the brain and heart, live much longer than others. They also found that proteins interacting with each other often have similar lifespans, and that specific chemical modifications like phosphorylation can either stabilize or destabilize key proteins—such as those involved in Alzheimer’s and Parkinson’s diseases.
The team created an online tool that lets other scientists explore this rich dataset. The findings can help understand tissue function better and may lead to new ways to treat diseases by targeting protein stability.
Practical Implementation/ Social Implications of the Research
Practical Implementation:
This turnover atlas provides a foundational resource for drug development and tissue-specific disease research. It supports AI-driven approaches to predict protein dynamics, aids in identifying long-lived disease-related proteins, like Tau and α-synuclein, and enhances biomarker discovery for neurodegenerative and metabolic diseases. The integrated tool Tissue-PPT allows researchers to explore and analyze protein lifespan and phosphorylation patterns across tissues.
Social Implications:
Understanding how proteins behave differently across tissues could help create more precise therapies for complex diseases such as Alzheimer’s, Parkinson’s, and cardiomyopathies. The dataset empowers researchers globally to explore protein turnover without relying heavily on animal experiments, advancing ethical and efficient biomedical research.
Collaborations
- Yale University School of Medicine, CT, USA
- St. Jude Children’s Research Hospital, TN, USA
- University Medical Center Göttingen, Germany
- University of Trieste, Italy
- West China Hospital, Sichuan University, China
Future Research Plans
The next phase will focus on AI-driven modeling of site-specific phosphorylation turnover in relation to disease phenotypes, using the Tissue-PPT dataset as a foundation. This includes integrating proteomics, phosphoproteomics, and transcriptomic data to refine our understanding of proteome regulation. Special attention will be given to how phosphorylation modulates the stability of neurodegenerative disease proteins and the development of targeted dephosphorylation therapeutics (e.g., PhosTACs).
This research aims to inform personalised interventions and identify novel therapeutic targets by understanding how tissue-specific protein lifespans are regulated under physiological and pathological conditions.
- Published in CSE NEWS, Departmental News, News, Research News
Two-Day Workshop on Applied Econometrics & Its Applications in STATA and R
The Department of Economics at Easwari School of Liberal Arts successfully organised a two-day workshop titled “Applied Econometrics: Leveraging with Software and Databases” on March 7 – 8, 2025. The workshop witnessed the participation of approximately 40 attendees, comprising academicians, research scholars, and students from various institutions, including SRM IST, VIT-AP and Amrita University. The significant turnout reflected the keen interest in applied econometrics and the practical implementation of statistical software (R and STATA) for economic analysis.
The primary objective of the workshop was to provide a comprehensive understanding of econometric principles while emphasising hands-on training with statistical software such as STATA and R. Participants received practical exposure to key econometric techniques, including time series modelling, cross-sectional data analysis, and panel data estimation, thereby enhancing their empirical research capabilities.
The workshop featured four insightful sessions conducted by distinguished experts in the field of econometrics:
- Dr Anandarao Suvvari (IIT Goa) – Delivered an in-depth session on fundamental econometric techniques and their applications in STATA and R.
- Dr Mohan Rao Balaga (IIT Dharwad) – Provided a comprehensive analysis of time series methodologies, covering ARIMA, VECM, VAR, and ARDL models using macroeconomic and financial datasets.
- Dr Pratap C Mohanty (IIT Roorkee) – Delivered a session on cross-sectional data techniques, encompassing linear and non-linear models, instrumental variable (IV) estimation, and applications utilizing NSSO and large-scale survey data.
- Dr Vineesh Prakash (SRM University-AP) – Conducted an extensive session on panel data models, discussing Fixed Effects (FE), Random Effects (RE), Generalized Method of Moments (GMM), and dynamic panel models using CMIE ProwessIQ data.
The interactive nature of the sessions enabled participants to engage with the resource persons, deliberate on real-world econometric applications, and undertake practical case studies utilizing empirical datasets. The rigorous discussions and hands-on exercises significantly contributed to a deeper understanding of applied econometrics.
This two-day workshop proved an enriching academic initiative, equipping participants with essential econometric skills and strengthening their analytical capabilities in economic and financial data analysis. The positive feedback from attendees underscored the effectiveness of the workshop particularly in integrating theoretical knowledge with hands-on implementation.
- Published in Departmental News, Economics Current Happenings, Economics News, News
“Democracy Unravelled” – International Conference on Exploring the South Asian Political Perspective
Academicians, research scholars, and social scientists from renowned institutions across the world assembled at the two-day international conference on “Democracy’s Undoing: South Asia and its Polities” hosted by SRM AP on March 20-21, 2025, to explore the pressing issues and challenges faced by various democracies in South Asia. The conference organised under the aegis of the Department of Political Science, Easwari School of Liberal Arts, explored the concept of democracy and its relevance to the current political landscape in South Asia.
Prof. Vishnupad, Dean – Easwari School of Liberal Arts set the tone for the conference in his welcome address. He deliberated on various aspects of democracy and shared the vision behind Easwari School of Liberal Arts, now home to seven vibrant departments, each oriented towards the holistic growth of its students— intellectual, emotional, and ethical. Dr Idris Hassan Bhat, Assistant Professor of the Department of Political Science and the convener of the conference, addressed the resilience of democratic ideals in South Asian nations.
Prof. Ashok Acharya, from the Department of Political Science, University of Delhi, delivered the first keynote session on the contextual explorations of liberalism. He examined liberal values and how they align with democracy in today’s complex political climate. Tracing the relationship between liberalism and democracy, Prof. Acharya stated, “The 20th century saw democracy take root as a regime, while liberalism functioned as a guiding ideology with an emphasis on liberty, self-governance, and diversity.” He elaborated on the significance of ‘dissensus’ in a liberal democratic society.
The second keynote address welcomed Dr Kurt Annen, a Professor of Economics at the University of Guelph, Ontario, Canada, who offered a global perspective on democracies. One of the central themes of the lecture was the challenge of establishing a clear causal relationship between democracy and economic growth. He also highlighted the importance of understanding the mechanisms through which democracies may foster economic development.
The conference also featured thought-provoking panel discussions, roundtable sessions, and paper presentations on various topics, ranging from Religious Nationalism and Homeland Fantasies in South Asia to the State of Minorities in South Asia to the Challenges of Inequality and Poverty to Democracy, that provided intense academic engagement and fresh perspectives for the participants and students at the Easwari School of Liberal Arts.
- Published in Departmental News, News, Political Science News, Research News
An Algorithm that Redefines Employee Attrition Prediction Technology
Dr Vimal Babu, Associate Professor in the Department of Management along with his PhD scholar Ms Rukma R, have co-authored a research paper titled “Enhancement of New Random Forest Algorithm to Predict the Employee Attrition Rate.” Published in the International Journal of Enterprise Network Management (ABDC-B), the paper also includes contributions from Dr Vijaya Prabhagar M, Assistant Professor at IIM Jammu.
Their work focuses on improving machine learning techniques to better predict employee attrition, that is, the employees who are likely to leave the organisation. The study focuses on the impact of HR analytics adoption by applying algorithms to predict employee attrition. It uses the Random Forest algorithm to identify reasons for attrition. However, this algorithm can be slow due to the large number of decision trees it uses. To improve it, the study proposes a new method that selects the best decision trees using a technique called fractional factorial design, which outperforms all others in predicting employee attrition.
Abstract
The problem of employee attrition in every organisation concerns the employee turnover ratio, thereby increasing the cost of investment in human resources. Various factors are reasonable for the rapid attritions at different phases. The purpose of the current study is to predict the employees who are likely to leave the organization. The factors that lead to attrition are identified using the Random Forest algorithm. The Random Forest algorithm is a widely used supervised machine-learning technique for classification and prediction. However, the random forest algorithm has certain issue like it is too slow and ineffective for real time predictions. i.e., the large number of trees can make the algorithm, which results in a slower model. Therefore, the study proposes, a new alternative for choosing the appropriate decision trees based on the concept of fractional factorial design of experiments. The different performance criteria were compared across the modified random forest algorithm, existing random forest algorithm, Support Vector Machine (SVM), Logistic Regression (LR), Navie Bayes (NB), K – Nearest Neighbour (K-NN), Decision Tree, XG Boost tree and Neural Network (NN). It was found that the modified random forest algorithm excelled in all criteria and performed better than the existing ones.
Practical Implementation/Social Implications of the Research
Practical implication: It emphasises the importance of focusing on factors like Business Travel, Job Role, Over Time, Department, Marital Status, and Education to reduce employee attrition. Organisations should design retention programs that support frequent travellers, manage overtime effectively, and address specific departmental needs. Tailoring job roles, promoting work-life balance through flexible hours, and providing educational opportunities are key strategies for enhancing employee satisfaction and retention.
Social Implication: The measures of this study can transform work culture into a more supportive and inclusive environment, promote gender equality by supporting employees with family responsibilities, and contribute to economic stability through reduced attrition. By investing in employee well-being, organizations can also strengthen their community engagement and corporate social responsibility initiatives for both employees and the broader society.
Future Research Plans
Future research could explore other factors influencing employee attrition, such as organizational culture, leadership style, and employee engagement. Longitudinal studies could track changes over time to understand the long-term effects on attrition rates. Additionally, investigating the interplay between identified factors, such as how Job Role and Over Time influence attrition, could provide deeper insights. Expanding the study across different industries and locations may reveal specific trends, allowing for tailored retention strategies. Lastly, incorporating qualitative methods like interviews and focus groups could offer a richer understanding of employees’ experiences and perceptions, complementing the quantitative findings.
- Published in Departmental News, News, Paari Current Happenings, Research News
Dr Amit Chakraborty and Scholar Publish their Research in Nature Index Journal
Dr Amit Chakraborty, Assistant Professor in the Department of Physics and Ms Shreecheta Chowdhury, PhD Scholar, have co-authored a research paper titled “Boosted top tagging through flavour-violating interactions at the LHC”, which has been published in the European Physical Journal C (Nature Index), Q1 Journal having an impact factor 4.2.
Their research focuses on identifying a rare process involving the top quark, one of the heaviest particles. In this rare decay, the top quark transforms into a charm quark and a Higgs boson, which then breaks down into two b quarks. The team uses the data collected at the Large Hadron Collider (LHC), the world’s largest particle smasher, and employs Machine Learning techniques to investigate the possibility of understanding these collision events and identifying signatures of physics Beyond the Standard Model.
Abstract
This paper describes a method for detecting a rare top quark decay into a charm quark and a Higgs boson (H), which decays further into b quarks, at the Large Hadron Collider (LHC), and introduces a tagging algorithm to identify boosted tops using large-R jets containing b- and c-tagged elements. We consider the associated production of the top quark with a W-boson and identify different observables to discriminate the signal from the Standard Model (SM) background events. Although our model with improved jet substructure methods outperforms existing approaches to tag such rare decay tops, the improvement in the New Physics reach in terms of t → cH branching ratio is marginal, even at the high luminosity run of LHC, compared to the existing limits from the LHC 13 TeV data. Additionally, the paper utilizes SHAP, a Game Theory-based method, to analyse the contribution of each observable to the classification of events, offering valuable insights into the classifier.
Future Research Plans
The team plans to explore Beyond Standard Model (BSM) physics through collider phenomenology. Leveraging the Higgs boson as a portal, they aim to investigate its potential role in dark matter interactions, neutrino mass generation, and possibly being part of a larger scalar sector. Additionally, Dr Chakraborty will delve into ultra-light particle searches and develop novel jet physics techniques using advanced Machine Learning (ML) algorithms for particle identification and classification. A crucial aspect of his work will be creating testable search strategies, ensuring direct comparison with experimental data from current and future colliders.
- Published in Departmental News, News, Physics News, Research News
Chemistry Student Secures Prestigious HEST Scholarship
Department of Chemistry is proud to announce that Mr M V R Akshay Sampath, 3rd year BSc. Chemistry student has been selected for the HEST Scholarship, India’s largest Higher Education Scholarship Test powered by WeMakeScholars, an organisation funded and supported by the Ministry of Electronics & Information Technology (MeitY), Govt. of India under the ‘Digital India’ campaign. Through this scholarship, Mr Sampath is eligible for scholarship funding of ₹3 lakhs, which can be utilized towards tuition fees, academic expenses, or travel costs for higher education.
Along with academics, Akshay is working in the functional nanomaterials laboratory under the supervision of Dr Sabyasachi Chakrabortty and in computational chemistry research under the supervision of Dr Baswanth V S Oruganti, Chanakya University, Bangalore. This opportunity significantly supports his aspirations for higher education and research in the branches of bio-photonics and material science in the top research-intensive universities globally in countries like Germany, UK, Ireland, and the USA.
- Published in Chemistry-news, Departmental News, News
Film Gala 2025: Exploring Novel Media of Storytelling
The Film Gala 2025, organised by the CineMates Club of SRM AP, was inaugurated with a formal ceremony that marked a prestigious two-day celebration dedicated to the art of cinema, narrative excellence, and creative expression. This distinguished event established a professional forum for filmmakers, artists, and cinema enthusiasts from across the nation to participate in intellectual discourse, competitive showcases, and cultural exhibitions.
The ceremony was honoured by the presence of Mrs Tejaswi Podapati Macharapu, Chairperson of the AP State Creativity and Culture Commission, Government of Andhra Pradesh, who served as the Chief Guest. She was accompanied by Mr Sujith Kalluri, Chief Club Advisors, distinguished faculty members, Founders and Alumni of CineMates, and official representatives from the organising committee.
The keynote address by Chief Guest Mrs Tejaswi Podapati Macharapu constituted the ceremony’s centrepiece. She delivered a comprehensive discourse on cinema’s transformative role in contemporary society. Drawing from her academic experiences, she emphasised the importance of integrating creative pursuits with scholastic endeavours. Mrs Tejaswi noted that India maintains its position as the world’s foremost film-producing nation, with an annual output exceeding 2,000 cinematic productions, thereby presenting substantial opportunities for aspiring filmmakers. She further emphasised that students from diverse academic disciplines, including engineering, possess the analytical acumen and creative capabilities necessary for success in the film industry.
To reinforce her message, Mrs Tejaswi referenced distinguished individuals from various professional domains, including politics, athletics, and the arts, underscoring how perseverance and passion are fundamental elements of professional achievement. She concluded her address by expressing admiration for the Film Gala’s established legacy and commended SRM AP for its institutional commitment to advancing artistic initiatives.
The ceremony featured classical dance performances by Ms. Preeti and Ms. Deepthi, who demonstrated the artistic interpretation of narrative through choreographed movement, exemplifying the intersection of traditional cultural expression and contemporary storytelling techniques.
A significant component of the inauguration was the formal announcement of the 24-Hour Filmmaking and Editing Challenges. The Visual Chase competition specified that participants create a two-minute video exploring the theme “Nature Speaks to Me,” while the Classic Cut competition challenged contestants to produce a trailer for the film ‘Kalki 2898 A.D.,’ with a maximum duration of 2 minutes and 30 seconds.
The inaugural ceremony concluded with a comprehensive presentation of the day’s scheduled activities, including curated short film screenings, a poetry recitation session, and an evening film presentation. The enthusiastic participation from attendees signified the successful launch of Film Gala 2025, establishing an auspicious foundation for what promised to be an intellectually stimulating and culturally enriching festival.
The event received generous sponsorship from esteemed organisations including Sastri Balm, AWEC Consultancy, IVY Overseas, ATHER, Vastrakala Shopping Mall, Picxy, Harivillu Promoters and Developers Pvt. Ltd., V1 Overseas Careers Pvt. Ltd., and GTR Solar Power. Their valued support facilitated the creation of a platform where emerging talents could demonstrate their artistic vision and technical expertise.
- Published in Departmental News, News, student affairs news, Students Affairs Events
Honourable Chief Minister of AP Applauds SRM AP on Infrastructure Planning & Augmentation
“SRM University-AP is a proof of concept of a visionary state, similar to Hitech Hyderabad a proof of united Andhra.” – Honourable Chief Minister of Andhra Pradesh, Shri Nara Chandrababu Naidu
SRM University-AP had the privilege of welcoming the Honourable Chief Minister of Andhra Pradesh, Shri Nara Chandrababu Naidu on campus on March 11, 2025. The Honourable CM, who visited the campus as the chief guest of the Conference of Population Dynamics and Development, organised under the auspices of the Planning Department, Government of Andhra Pradesh, held an exclusive interaction with the leadership and management of SRM University-AP on infrastructure planning, development and execution of the upcoming projects.
The leadership team of SRM AP, headed by the Chancellor Dr T R Paarivendhar, Pro-Chancellor Dr P Sathyanarayanan, Vice Chancellor Prof. Manoj K Arora, Executive Director – Research, SRM Group of Institutions, Prof. D Narayana Rao and Registrar, Dr R Premkumar, showcased the exemplary growth of the university emphasising the establishment of various new-age infrastructure and facilities catering to foster a future-ready academic community.
Prof. D Narayana Rao presented the Honourable CM with the university infrastructure planning and development plan and execution period for the same in the upcoming years. He gave a comprehensive overview of the future projects, including the proposed Centre for Green Hydrogen & Clean Energy Innovation, Centre for Quantum Computing, Centre for Interplanetary Exploration, SRM Medical College, AI Institute, Skilling Academy, etc. Prof. Rao assured that SRM AP would strive towards becoming a centre for transformative learning, research innovations and a successful startup incubator and sought the required support from the Government, by allocating the required resources.
In his interaction with the Honourable CM, Chancellor Dr T R Paarivendhar stated, “We follow our respected Chief Minister Shri Chandrababu Naidu’s vision to transform Amaravati into an innovation hub, and Green Co. SRM University-AP as a new-age holistic university align our strategic goals for development in cognisance to CM’s pioneering vision of Swarn Andhra Vision 2047.”
The Honourable CM congratulated the apex team of the university on its outstanding progress in the seven years, paving the path of learning and growth in Andhra Pradesh. He opined that the future is Internet of Things, Quantum Computing and Green Energy. With SRM AP being a leader in tertiary education, he advised that the university develop a strong workforce of designers, coders, and experts with skills in algorithms and hardware who are pivotal in building a progressive state. The Honourable CM recommended SRM AP to lead the startup ecosystem and produce more entrepreneurs by establishing a dedicated Centre for Innovation and Startup ecosystem.
The Honourable CM inaugurated two newly constructed buildings at SRM AP: C V Raman Block and Ganga Hostel Block (Residential facility for students). In addition, the Honourable CM laid the foundation stones for four new buildings: Industrial Research Park, Academic Cluster, Ganga-B Hostel Block, and Vedavathi-II Hostel Block.
The distinguished visit from the Honourable Chief Minister Shri Chandrababu Naidu is a testament to the relentless support and visionary direction he has offered to SRM University-AP throughout the years. Pro-Chancellor Dr P Sathyanarayanan remarked, “The perceptive insights of the Honourable Chief Minister on SRM University-AP’s initiatives and prospects have aided in aligning our development plans with the objectives of national education.”
SRM AP has made remarkable progress in its infrastructural, academic, and institutional student placement record. The unwavering support and resources from the Government of Andhra Pradesh encourage the university to become globally connected, regionally transformative, and nationally relevant.
- Published in News
SRM AP, Amaravati’s Landmark Collaboration with Carnegie Mellon University’s School of Computer Science, USA for AI Research, Education
SRM AP, Amaravati, is proud to announce a transformative five-year collaboration with Carnegie Mellon University’s School of Computer Science (CMU SCS), USA-one of the world’s foremost institutions in artificial intelligence (AI) and cutting-edge research. This strategic collaboration aims to push the boundaries of knowledge, innovation and education in AI-related disciplines, including machine learning, natural language processing, computer vision, infrastructure and systems, and AI ethics and policy.
At the heart of this collaboration is a shared vision to foster an ecosystem that nurtures groundbreaking research, cultivates exceptional talent, and accelerates advancements in AI-driven technologies.
A Pioneering Collaboration for AI Excellence
“CMU’s School of Computer Science is excited to work with SRM AP, Amaravati, on this landmark collaboration to advance research and bolster AI education. Together, we will shape the future of AI and empower the next generation of researchers, educators and industry leaders to push the frontiers of technology and drive meaningful change in society,” said Prof. Martial Hebert, Dean of CMU’s School of Computer Science.
Empowering Research Through Global Collaboration
As part of this collaboration, SRM AP, Amaravati’s research faculty and researchers will have the opportunity to engage directly with the esteemed faculty and researchers at CMU’s School of Computer Science. They will immerse themselves in CMU SCS’s pioneering AI labs, working alongside global experts in key research domains. This will facilitate research, knowledge sharing and the development of state-of-the-art AI innovations that address real- world challenges.
Dr P Sathyanarayanan, Pro-Chancellor of SRM AP, Amaravati, said that “To further strengthen research capabilities, this collaboration will also pave the way to establish advanced AI labs at SRM AP, Amaravati. These labs will be incubators for novel AI research, fostering a stimulating environment that promotes academic rigor, interdisciplinary collaboration and technological innovation”.
Advancing AI Education with World-Class Learning Opportunities
Beyond research, this collaboration is designed to enrich the academic experience of SRM AP’s teaching faculty and research scholars. Selected faculty members and scholars can audit cutting-edge AI courses at CMU’s School of Computer Science as visiting participants. This exposure will allow them to engage with CMU SCS faculty and contribute to developing robust AI curricula at SRM AP. They will also gain hands-on experience in designing assignments, worksheets and examinations that mirror real-world AI problem-solving scenarios, enhancing the quality of AI education at SRM AP, Amaravati,.
Unparalleled Research Internships for Students
Prof. Manoj K Arora, Vice Chancellor expressed, “In a move that underscores its commitment to nurturing future AI leaders, the collaboration will offer SRM AP students the opportunity to undertake research internships at CMU’s School of Computer Science.”
Selected students will spend approx. six weeks each summer immersed in a world-class research environment, gaining firsthand experience in tackling complex AI challenges alongside leaders in the field. This experience will provide students with unparalleled insights and exposure to global research methodologies, setting them apart in the highly competitive AI landscape.
By leveraging CMU SCS’s expertise and SRM AP’s commitment to academic excellence, this collaboration will drive innovation, expand knowledge horizons and create a lasting impact on the AI ecosystem between the universities.
- Published in Collaborations, News, Research News
Guest Talk on an Overview of HR in Corporate
The Department of Management organised a Guest Talk on “Business Communication; Overview of HR Department in a Corporate”. Mr Sannu Francis, General Manager of Orient Cement, delivered the session on the role of HR as a strategic partner, aligning talent management with overall business objectives.
Mr Francis remarked that the role of HR begins with manpower planning; determining the right number of employees, structuring budgets, and forecasting production needs based on market trends. HR is responsible for recruiting and onboarding the right talent through sourcing, competency-based interviews, and psychometric testing. Once onboard, HR focuses on developing employees through training and learning initiatives that enhance knowledge, skills, and attitudes. It manages performance by setting clear goals, conducting mid-year reviews, and overseeing annual appraisals, ensuring fairness and objectivity.
Additionally, he stated that HR administers compensation, benefits, and statutory payments while upholding compliance and legal standards. Beyond these functions, Mr Francis said that effective communication: verbal, nonverbal, written, and visual; is key to fostering strong relationships and engagement within the organization, making HR indispensable for driving business success.
The session gave a comprehensive overview of the significance of HR in a Corporate and the importance of business communication.
- Published in Departmental News, News, Paari Current Happenings, paari-guest-lectures