Unlocking Cholesterol Homeostasis: A Mathematical Modelling Perspective
In a significant stride towards understanding cholesterol homeostasis, Dr Koyel Chakravarty, Assistant Professor and Mr Sukdeb Manna, a PhD Scholar in the Department of Mathematics has co-authored a paper titled “Unlocking Cholesterol Homeostasis: A Mathematical Modelling Perspective.” The paper has been published in the esteemed journal, The European Physical Journal Plus, with an impact factor of 3.4. This collaborative effort showcases the innovative application of mathematical modelling in unravelling the complexities of cholesterol regulation within the body.
The research not only contributes to the existing body of knowledge in this field but also sheds light on potential avenues for further exploration and understanding. Dr Chakravarty and Mr. Manna’s work underscores the importance of interdisciplinary approaches in scientific research and highlights SRM University-AP’s commitment to fostering cutting-edge research and innovation.
Their collaborative efforts serve as an inspiration to aspiring researchers and underscore the university’s dedication to pushing the boundaries of knowledge and discovery. Congratulations to Dr Chakravarty and Mr Manna on this remarkable achievement, and we look forward to more groundbreaking contributions from them in the future.
Abstract:
Limited progress in the mathematical modelling of cholesterol transport systems is hampering novel therapeutic interventions. This issue is addressed by the present study through precise design, employing four compartmental models to elucidate cholesterol dynamics in the comprehensive bloodstream. Disparities in medical advancements, particularly in cholesterol-related pathophysiology, are aimed to be bridged, advancing medical science and patient care outcomes.
Therapeutic strategies for reducing blood cholesterol are explored by the model, with parameter influences on equilibrium stability revealed through sensitivity analysis. System parameters are effectively manipulated by imposing sensitivity analysis, and pinpointing areas for model refinement. Stability analysis contributes to diverse realistic models, confirming local asymptotic stability. Model efficacy in studying cholesterol transport dynamics is supported by analytical and numerical assessments. The study concludes with the present model validation to substantiate it by comparing the present outcomes with the existing ones.
Explanation of The Research in Layperson’s Terms:
Basically, scientists are having trouble figuring out how to model how cholesterol moves around in the body, which is important for developing new treatments. This study tries to solve that problem by creating detailed models that show how cholesterol behaves in different parts of the bloodstream. The goal is to bridge the gap in medical knowledge about cholesterol-related problems and improve how we treat patients. The models help us understand how different treatments might affect cholesterol levels, and by analyzing them closely, we can figure out which factors are most important. This lets us tweak the models to make them more accurate. The study shows that the models are reliable by testing them both analytically and numerically, and comparing the results to what we already know.
Practical Implementation or the Social Implications of the Research
1. Personalized Medicine: The mathematical models developed in this research could help in designing personalized treatment plans for individuals with high cholesterol levels. By understanding how different factors affect cholesterol dynamics, doctors can tailor therapies to each patient’s specific needs, leading to more effective and targeted treatments.
2. Drug Development: Pharmaceutical companies could use these models to screen potential drugs for lowering cholesterol. By simulating how different compounds interact with cholesterol transport systems, researchers can identify promising candidates for further testing, potentially speeding up the drug development process.
3. Healthcare Cost Reduction: Better understanding of cholesterol dynamics could lead to more efficient use of healthcare resources. By optimizing treatment strategies and preventing complications related to high cholesterol, healthcare costs associated with conditions like heart disease could be reduced, benefiting both individuals and society.
4. Public Health Initiatives: Insights from the research could inform public health initiatives aimed at reducing cholesterol-related diseases. For example, policymakers could use the models to design targeted interventions such as education campaigns promoting healthy lifestyle choices or policies to improve access to cholesterol-lowering medications.
5. Improved Patient Outcomes: Ultimately, the goal of this research is to improve patient outcomes by better understanding and managing cholesterol homeostasis. By developing more accurate models of cholesterol transport dynamics, healthcare providers can make more informed decisions, leading to better control of cholesterol levels and reduced risk of cardiovascular disease and other related conditions.
Future Research Plans:
1. Current models may focus on a limited set of factors influencing cholesterol transport. Future research could explore the integration of additional biological factors such as genetic variations, hormonal influences, and dietary components into the models to create a more comprehensive understanding of cholesterol homeostasis.
2. Most existing models of cholesterol transport assume static conditions. Future research could develop dynamic models that capture the time-dependent changes in cholesterol levels in response to various stimuli, such as meals, physical activity, and medication intake. Dynamic models would provide a more accurate representation of real-world cholesterol dynamics and enable the evaluation of time-sensitive interventions.
Picture Related to the Research
- Published in Departmental News, Math News, News, Research News
#NoExcusesDay: Promoting Voter Awareness and Responsibility
On the auspicious occasion of advocating for voter awareness and responsibility, a “#NoExcusesDay” event was held at SRM University-AP on May 09, 2024, organised by the Times of India and the Directorate of Communications of the university. The event, graced by Chief Guest, Mr Harendhira Prasad, Additional Chief Electoral Officer, aimed to emphasise the significance of voting in a democracy and to motivate citizens, especially the youth, to exercise their right to vote without fail.
The event commenced with the display of a motivating video message from President Draupadi Murmu, setting the tone for the importance of active participation in the electoral process. Highlighting the statistics of voting percentages in assembly elections from Hyderabad, the video presentation was followed by an address by Mr Rajiv Kumar, the Chief Election Commissioner, who underscored the importance of adding 97 crore voters to the electoral rolls.
The introduction of technology in the electoral process was a key point of discussion, with emphasis placed on the utilisation of advanced methods to ensure smooth and efficient polling. The staggering number of 10.5 lakh polling stations across the nation further underscored the magnitude of the electoral process.
Under the theme “Chunav Ka Parv Desh Ka Garv” (Festival of Elections, Pride of the Nation), the event witnessed active participation from students and faculty members alike. Mr Pankaj Belwariar, Director of Communications, and Mr Anil Nigam, Director of Student Affairs, graced the stage to extend their support and encouragement towards fostering a culture of voting. The event also provided a platform for students to share their first-time voting experiences. M. Kartika, Y. Ramya, V. Suma, and Tamineni Harnan Reddy shared their personal anecdotes, underscoring the sense of responsibility and empowerment that comes with casting a vote.
Mr Pankaj Belwariar’s impassioned speech resonated with the audience as he articulated the significance of treating voting as a non-negotiable duty. His “no-excuse day” message struck a chord, urging individuals to overcome obstacles and prioritise their democratic duty. Mr Anil Nigam elaborated on the disparities between rural and urban voting patterns, highlighting the heightened enthusiasm observed in rural areas. Aditya Challa, a fourth-year student, emphasised the symbiotic relationship between voting and the right to question, asserting, “No vote, no right to question.”
The event reached its pinnacle with the chief guest, Mr Harendhira Prasad’s speech, where the imperative nature of May 13th, termed as “D-day” for both assembly and Lok Sabha elections, was underscored. Stressing the importance of carrying approved identification cards for casting votes, the chief guest reiterated that voting is not just a right but a solemn duty that every citizen must fulfil.
The significance of the None of the Above (NOTA) option was elucidated, serving as a powerful tool for citizens to express dissent and demand accountability from political parties. The chief guest, Mr Harendhira Prasad, made a humble request for citizens to fulfil their duty with the same diligence as those involved in organising the elections, resonating deeply with the audience.
In conclusion, the event served as a poignant reminder of the privileges and responsibilities inherent in a democratic society. Through informative sessions, personal anecdotes, and impassioned speeches, attendees were galvanised to embrace their role in shaping the future of the nation through the simple yet profound act of voting. As May 13, 2024 approaches, the call to action reverberates loud and clear: no excuses, only votes.
- Published in News
Film Gala 2024: A Spectacular Showcase of Talent and Creativity
On April 24-25, 2024, the much-anticipated Film Gala 2024 unfolded by SRM University-AP’s Cinemates Club, under the Directorate of Student Affairs, igniting the creative fervour of budding filmmakers from universities across India. This exhilarating event provided a vibrant platform for these talented individuals, budding to exhibit their cinematic prowess.
Graced by the presence of esteemed Tollywood actor Satya Dev and actress Archana as chief guests, the event was a star-studded affair filled with entertainment and enlightenment. Attendees were treated to mesmerizing dance performances, soulful music, engaging discussions, pulsating DJ sets, and a celebration of artistic brilliance that left everyone inspired.
The atmosphere at the Gala was electric, as aspiring filmmakers seized the opportunity to have their talents acknowledged and applauded. The Film Gala hosted an array of thrilling competitions, each pushing the boundaries of creativity:
- Cineverse: Where Stories Unfold: A short film competition that transported audiences through captivating narratives.
- Snake and Ladders: A playful twist on storytelling where every move leads to unexpected turns.
- Plot Saga: Your Journey With Scripts: A celebration of the art of scriptwriting, where imagination knew no bounds.
- Trailer Trek: Filmmakers raced against the clock, crafting gripping trailers that left viewers craving more.
- Cinerythm: Western dance took centre stage, with both group and solo performances.
- Character Canvas: Participants embodied iconic movie characters, showcasing their versatility.
- Galasymphony: The spotlight shifted to melodious voices in a spirited singing competition.
- Visual Fable: Every frame held a story, as participants created videos based on a central theme.
- Movie Night: A cinematic feast under the stars, where films came alive on the big screen.
- Cinematography Workshop: Aspiring cinematographers honed their skills, learning from industry experts.
The Film Gala was more than an event; it was a celebration of artistic brilliance. Aspiring filmmakers seized the opportunity to have their work recognized and appreciated. Their passion and dedication illuminated every corner of the venue, leaving an indelible mark on the cinematic landscape. Congratulations to the organisers, participants, students and everyone who contributed to making the Film Gala 2024 an unforgettable success!
- Published in News, student affairs news
Patent Granted for Research in Developing Tarnish Resistant Silver Alloys
Yet another groundbreaking achievement for the researchers at SRM University-AP! Prof. Ranjit Thapa, Dean-Research and Professor, Department of Physics, Prof. G S Vinod Kumar, Professor and Head, Department of Mechanical Engineering and Ms Harsha K, PhD scholar, continue to make their mark in the university’s excellent research legacy by having their patent “Tarnish Resistant Silver Composition and a Process for its Preparation” being granted by the Indian Patent Office. This innovative research team has used density functional theory to explain the tarnishing of silver. Their work also focuses on finding alloying elements that protect silver.
Abstract
The research is on the development of tarnish-resistant silver alloys from an experimental and computational perspective. With time, silver atoms on the surface of the metal undergo sulphidation and form Ag2S molecules. These particles will accumulate to form a layer whose thickness goes beyond 10nm, and then the human eye will start to find a discolouration on the surface of silver, which is tarnish. The stain colour changes from light yellow to dark brown. This reduces the lustre of silver and makes them aesthetically non-pleasing. The silver jewellery and articles manufacturing industry suffers from this tarnishing as it leads to the loss of material and money and ruins intricate designs made of silver. The research study attempts the problem by alloying silver with appropriate elements, which are computationally checked and verified. The team works with alloying elements such as Cu, Zn, Ge, Ti, Zr, Mg, Al, and Be. Along with tarnish resistance, the proposed alloys maintain high reflectance, good hardness, and excellent workability when spinning.
Figure.1 The images of different silver alloys after accelerated tarnish test in as-cast condition (first row) and after undergoing passivation heat treatment at 450°C for 1 hour in the presence of oxygen (second row).
Practical implementation/social implications of the research
- Stainless silver is in demand as customers want their precious metal articles to be kept for a longer time as heirlooms. So, the product that we could develop out of our composition will be making more demand for silver.
- It can increase the market potential of silver.
- It can lead to more innovations in the jewellery industry.
Collaborations
- Waman Hari Pethe
- Ashlyn Chemmannur
- TITAN
The team would continue to work on the scope of research to develop more tarnish-resistant compositions, improve the tensile strength, scratch resistance, surface hardness, and workability of silver alloys and find novel elements which can add to desirable properties of silver.
Figure.2 Reflectance of alloys (a) before tarnish test (b) after tarnish test
- Published in Departmental News, Mechanical Engineering NEWS, News, Physics News, Research News