All Management Events

DNP India

Continue reading →

The New Indian Express

Continue reading →

The Hindu

Continue reading →

The Hindu

Continue reading →

The Economic Times

Continue reading →

Dr Abhijit Dasgupta, Assistant Professor from the Department of Computer Science and Engineering, has published his breakthrough research article titled “Turnover Atlas of Proteome and Phosphoproteome Across Mouse Tissues and Brain Regions” in the nature index journal Cell having an impact factor of 45.5.

Abstract

This study presents a comprehensive in vivo atlas of protein and phosphoprotein turnover across 16 mouse tissues and brain regions, integrating advanced mass spectrometry with stable isotope labeling. By mapping over 11,000 proteins and 40,000 phosphosites, the study reveals tissue-specific patterns of protein lifetimes, correlating them with abundance, function, and protein-protein interactions (PPI). It highlights how phosphorylation regulates protein stability and how turnover is linked to peroxisome function, ubiquitination, and neurodegeneration-associated proteins such as Tau and α-synuclein. This high-resolution resource enhances our understanding of proteostasis and dynamic protein regulation, providing new insights into tissue-specific physiology and disease mechanisms.

Explanation of the Research in Layperson’s Terms

All cells in the body continuously make and break down proteins. The balance of these processes—called protein turnover—is vital for keeping tissues healthy. But until now, scientists didn’t have a clear, detailed map of how protein turnover works across different tissues and brain regions.

In this study, researchers used advanced techniques to measure how long thousands of proteins and their phosphorylated (chemically modified) versions last in 16 parts of the mouse body. They discovered that some proteins, especially in the brain and heart, live much longer than others. They also found that proteins interacting with each other often have similar lifespans, and that specific chemical modifications like phosphorylation can either stabilize or destabilize key proteins—such as those involved in Alzheimer’s and Parkinson’s diseases.

The team created an online tool that lets other scientists explore this rich dataset. The findings can help understand tissue function better and may lead to new ways to treat diseases by targeting protein stability.

Practical Implementation/ Social Implications of the Research

Practical Implementation:

This turnover atlas provides a foundational resource for drug development and tissue-specific disease research. It supports AI-driven approaches to predict protein dynamics, aids in identifying long-lived disease-related proteins, like Tau and α-synuclein, and enhances biomarker discovery for neurodegenerative and metabolic diseases. The integrated tool Tissue-PPT allows researchers to explore and analyze protein lifespan and phosphorylation patterns across tissues.

Social Implications:

Understanding how proteins behave differently across tissues could help create more precise therapies for complex diseases such as Alzheimer’s, Parkinson’s, and cardiomyopathies. The dataset empowers researchers globally to explore protein turnover without relying heavily on animal experiments, advancing ethical and efficient biomedical research.

Collaborations

• Yale University School of Medicine, CT, USA
• St. Jude Children’s Research Hospital, TN, USA
• University Medical Center Göttingen, Germany
• University of Trieste, Italy
• West China Hospital, Sichuan University, China

Future Research Plans

The next phase will focus on AI-driven modeling of site-specific phosphorylation turnover in relation to disease phenotypes, using the Tissue-PPT dataset as a foundation. This includes integrating proteomics, phosphoproteomics, and transcriptomic data to refine our understanding of proteome regulation. Special attention will be given to how phosphorylation modulates the stability of neurodegenerative disease proteins and the development of targeted dephosphorylation therapeutics (e.g., PhosTACs).

This research aims to inform personalised interventions and identify novel therapeutic targets by understanding how tissue-specific protein lifespans are regulated under physiological and pathological conditions.

Read more

Continue reading →

The Hindu

The Hans India

The Pioneer

Eenadu

Andhra Prabha

Mangalagiri Times

Andhra Patrika

Surya

Vartha

Arth Prakash

Continue reading →

Dr Debajyoti Kundu, Assistant Professor at the Department of Environmental Science and Engineering in his research paper, Pharmaceuticals and Personal Care Products in Soil: Sources, Impacts and Myco-remediation Strategies, speaks of the innovative solutions to tackle contamination of soil. Dr Kundu’s research focuses on leveraging natural processes of fungi to promote sustainable environmental management.

Abstract:

Bioremediation is a sustainable approach for mitigating pharmaceutical and personal care product (PPCP) contamination in soil. This review highlights mycoremediation as an advanced fungal-based strategy for PPCP degradation. Fungi possess unique enzymatic pathways and metabolic diversity, allowing them to break down persistent pollutants in challenging environmental conditions. The paper discusses key fungal species, enzymatic mechanisms, environmental factors influencing degradation efficiency, and innovative biotechnological approaches such as myco-nanotechnology and enzyme engineering. By integrating these advancements with circular economy principles, this research underscores fungi’s role in sustainable environmental management.

Explanation in layperson’s terms:

Pharmaceuticals and personal care products (PPCPs), such as medicines, soaps, and cosmetics, often end up in the soil through wastewater and agricultural runoff. These chemicals persist in the environment, harming ecosystems and potentially entering our food supply. Our research explores how fungi, nature’s recyclers, can help clean up these pollutants. Certain fungi produce special enzymes that break down harmful substances into harmless compounds. By harnessing this natural process, we propose eco-friendly solutions to reduce pollution and protect soil and water quality for future generations.

Practical and Social Implications:

Mycoremediation offers a sustainable, cost-effective solution for removing PPCPs from soil, protecting water quality, and reducing human exposure to contaminants. By preventing pollutant uptake in crops, it enhances food safety and supports sustainable agriculture. This research also informs policies on wastewater treatment and pollution control, promoting eco-friendly remediation technologies for environmental and public health protection.

Collaborations:

This research is a collaborative effort involving experts from:

• Voice of Environment (VoE), Guwahati, Assam
• University of North Bengal, Darjeeling, West Bengal
• RCC Institute of Information Technology, Kolkata
• Sukanta Mahavidyalaya, University of North Bengal, Dhupguri, West Bengal
• SPMR College of Commerce, Jammu
• SRM University-AP, Andhra Pradesh
• CSIR – National Environmental Engineering Research Institute (CSIR-NEERI), Nagpur, India

Future Research Plans:

Future research will focus on scaling up my coremediation for field applications, optimizing fungal enzyme efficiency through enzyme engineering, and exploring microbial consortia for enhanced pollutant degradation. Myco-nanotechnology will be further developed to improve fungal stability and reusability. Additionally, studies will assess long-term soil health impacts and support policy frameworks for integrating fungal bioremediation into wastewater treatment and agricultural practices.

Continue reading →

The Department of Sociology and Anthropology at the varsity organised a round table talk, Ghumat Stories, as part of the SEED Grant proceedings awarded to Dr Sebanti Chatterjee, Assistant Professor at the department. The session explored the cultural and social significance of the ghumat, a traditional percussion instrument made of clay and crafted using the hide of the monitor lizard.

The event featured a diverse panel, including musician Mr Omar, documentary filmmaker Ms Nalini, musician Ms Sonia, researcher Ms Divya, ghumat player Mr Felipe, and dancer Ms Placania, alongside Dr Bikku, Head of the Department of Sociology and Anthropology, Dr Nishanth K S, other faculty members and students.

Ms Nalini’s documentary delved into the ghumat’s historical and cultural relevance. Musicians Mr Omar and Ms Sonia elaborated on the social and lyrical aspects of ghumat and folk dances such as Mannddô, that shed light on its connection to folk traditions.

Artists Felipe and Placania captivated the audience with live demonstrations. Felipe showcased how ghumat is played, while Placania performed the traditional folk dance associated with the instrument, while adorning the saree worn in a style particular to the dance.

Researcher Ms Divya provided insights into various folk song traditions linked to ghumat, including Mannddô. She classified these traditions within both the Mangalorean and Goan contexts, discussing how the ghumat functions as a “talking drum” in these folk traditions. Ms Divya further elaborated on the diverse tempos and occasions where ghumat-accompanied folk songs are performed.

Ms Divya also shed light on the craftsmanship of ghumat, explaining how Goan tribes such as the Kunbis, Karbis, and Siddhis procure, cure, and treat the hide of monitor lizard for the instrument’s making. She explained the transition of using goat skin in present times due to the prohibition of hunting the monitor lizards. Her discourse further highlighted the cultural and social significance of ghumat in folk communities today.

The session offered the attendees an understanding of the ghumat’s enduring legacy, and the tradition that will keep it alive in the contemporary cultural landscape.

 

Continue reading →