In a significant stride towards understanding cholesterol homeostasis, Dr Koyel Chakravarty, Assistant Professor and Mr Sukdeb Manna, a PhD Scholar in the Department of Mathematics has co-authored a paper titled “Unlocking Cholesterol Homeostasis: A Mathematical Modelling Perspective.” The paper has been published in the esteemed journal, The European Physical Journal Plus, with an impact factor of 3.4. This collaborative effort showcases the innovative application of mathematical modelling in unravelling the complexities of cholesterol regulation within the body.
The research not only contributes to the existing body of knowledge in this field but also sheds light on potential avenues for further exploration and understanding. Dr Chakravarty and Mr. Manna’s work underscores the importance of interdisciplinary approaches in scientific research and highlights SRM University-AP’s commitment to fostering cutting-edge research and innovation.
Their collaborative efforts serve as an inspiration to aspiring researchers and underscore the university’s dedication to pushing the boundaries of knowledge and discovery. Congratulations to Dr Chakravarty and Mr Manna on this remarkable achievement, and we look forward to more groundbreaking contributions from them in the future.
Abstract:
Limited progress in the mathematical modelling of cholesterol transport systems is hampering novel therapeutic interventions. This issue is addressed by the present study through precise design, employing four compartmental models to elucidate cholesterol dynamics in the comprehensive bloodstream. Disparities in medical advancements, particularly in cholesterol-related pathophysiology, are aimed to be bridged, advancing medical science and patient care outcomes.
Therapeutic strategies for reducing blood cholesterol are explored by the model, with parameter influences on equilibrium stability revealed through sensitivity analysis. System parameters are effectively manipulated by imposing sensitivity analysis, and pinpointing areas for model refinement. Stability analysis contributes to diverse realistic models, confirming local asymptotic stability. Model efficacy in studying cholesterol transport dynamics is supported by analytical and numerical assessments. The study concludes with the present model validation to substantiate it by comparing the present outcomes with the existing ones.
Explanation of The Research in Layperson’s Terms:
Basically, scientists are having trouble figuring out how to model how cholesterol moves around in the body, which is important for developing new treatments. This study tries to solve that problem by creating detailed models that show how cholesterol behaves in different parts of the bloodstream. The goal is to bridge the gap in medical knowledge about cholesterol-related problems and improve how we treat patients. The models help us understand how different treatments might affect cholesterol levels, and by analyzing them closely, we can figure out which factors are most important. This lets us tweak the models to make them more accurate. The study shows that the models are reliable by testing them both analytically and numerically, and comparing the results to what we already know.
Practical Implementation or the Social Implications of the Research
1. Personalized Medicine: The mathematical models developed in this research could help in designing personalized treatment plans for individuals with high cholesterol levels. By understanding how different factors affect cholesterol dynamics, doctors can tailor therapies to each patient’s specific needs, leading to more effective and targeted treatments.
2. Drug Development: Pharmaceutical companies could use these models to screen potential drugs for lowering cholesterol. By simulating how different compounds interact with cholesterol transport systems, researchers can identify promising candidates for further testing, potentially speeding up the drug development process.
3. Healthcare Cost Reduction: Better understanding of cholesterol dynamics could lead to more efficient use of healthcare resources. By optimizing treatment strategies and preventing complications related to high cholesterol, healthcare costs associated with conditions like heart disease could be reduced, benefiting both individuals and society.
4. Public Health Initiatives: Insights from the research could inform public health initiatives aimed at reducing cholesterol-related diseases. For example, policymakers could use the models to design targeted interventions such as education campaigns promoting healthy lifestyle choices or policies to improve access to cholesterol-lowering medications.
5. Improved Patient Outcomes: Ultimately, the goal of this research is to improve patient outcomes by better understanding and managing cholesterol homeostasis. By developing more accurate models of cholesterol transport dynamics, healthcare providers can make more informed decisions, leading to better control of cholesterol levels and reduced risk of cardiovascular disease and other related conditions.
Future Research Plans:
1. Current models may focus on a limited set of factors influencing cholesterol transport. Future research could explore the integration of additional biological factors such as genetic variations, hormonal influences, and dietary components into the models to create a more comprehensive understanding of cholesterol homeostasis.
2. Most existing models of cholesterol transport assume static conditions. Future research could develop dynamic models that capture the time-dependent changes in cholesterol levels in response to various stimuli, such as meals, physical activity, and medication intake. Dynamic models would provide a more accurate representation of real-world cholesterol dynamics and enable the evaluation of time-sensitive interventions.
Picture Related to the Research
