DST - Ramanujan Fellowship Faculty

Dr Satheesh Ellipilli

Department of Chemistry

Interests

  1. RNA nanoparticles
  2. Exosomes
  3. Drug Delivery

Faculty Details

Education

2006

Andhra University,
India
BSc

2008

Andhra University,
India
MSc

2015

Indian Institute of Science Education and Research, Pune
India
PhD

Experience

  • 2018-2021-Postdoctoral researcher-The Ohio State University, Columbus, USA.
  • 2017-2018-Postdoctoral Researcher-Emory University, Atlanta, USA.
  • 2016-2017-Postdoctoral Researcher-The University of Utah, Salt Lake City, USA.

Research Interest

  • Design and construction of RNA nanoparticles for targeted delivery of combination therapeutics to cancer and other diseases.
  • Use of extracellular vehicles (EVs) as a biocompatible drug delivery vehicle for cancer and other diseases
  • Engineering EVs as a targeted delivery vehicle by decorating EVs' surface with cell-specific targeting ligands
  • Development of diagnostic tools for various diseases using RNA nanotechnology

Awards & Fellowships

  • 2010-CSIR-Juniro Research Fellowship-IISER, Pune
  • 2012– CSIR-senior Research Fellowship– IISER, Pune
  • 2021-Ramanjuan Fellowship-SRM University

Publications

  • Fluorous Peptide Nucleic acids: PNA analogues with Fluorine in Backbone (γ-CF2-apg-PNA) Enhance Cellular uptake. S. Ellipilli and K. N. Ganesh. Journal of organic chemistry, 80, 9185-9191 (2015)
  • Perfluoroalkylchain conjugation as a New Tactic for Enhancing Cell Penetration of Peptide Nucleic Acids (PNA) via reducing the Nanoparticle size. S. Ellipilli, Murthy, R. K. N Ganesh. Chem. Comm., 52, 521-524 (2016)
  • Fluorinated Peptide Nucleic Acids with Fluoroacetyl Side Chain Bearing 5-(F/CF3)-Uracil: Synthesis and Cell Uptake Studies. S. Ellipilli, and K. N. Ganesh. Journal of organic chemistry, 81, 6364-6373 (2016).
  • Synthesis of Comb-shaped Branched DNA Using a Non-nucleosidic Branching Phosphoramidite. S. Ellipilli, J.D Phillips, and J. M. Heemstra. Organic & biomolecular chemistry, 16, 4659-4664 (2018)
  • Fluorogenic Photoaffinity Labeling of Proteins in Living Cells. T. M. Ayele, S. D. Knutson, S. Ellipilli, H. Hwang, and J. M. Heemstra, Bioconjugate Chemistry, 30, 1309-1313 (2019).
  • Multivalent Rubber-like RNA Nanoparticles for Targeted Co-delivery of Paclitaxel and MiRNA to Silence the Drug Efflux Transporter and Liver Cancer Drug Resistance. H. Wang, S. Ellipilli, W. Lee, X. Li, M. Vieweger, Y. Ho, P. Guo. Journal of Controlled Release, 330, 173-184 (2021). (Co-first author).
  • Thermostability, Tunability, and Tenacity of RNA as Rubbery Anionic Polymeric materials in Nanotechnology and Nanomedicine----Specific Cancer Targeting with Undetectable Toxicity. D. Binzel, X. Li, N. Burns, E. Khan, W. Lee, L. Chen, S. Ellipilli, W. Miles, Y. Ho, P. Guo. Chemical review, 121, 7398-7467 (2021)
  • Kurakula, H.; Vaishnavi, S.; Sharif, M. Y.; Ellipilli, S*. Emergence of small interfering RNA-based gene drugs for various diseases. ACS omega, 2023, 8, 20234-20250.

Contact Details

TOP