Assistant Professor

Dr Pulak Kar

Department of Biological Sciences

Interests

  • Cell biology
  • Molecular Biology
  • Biochemistry

Faculty Details

Education

2001

University of Calcutta
India
BSc

2003

University of Kalyani
India
MSc

2009

University of Kalyani
India
PhD

Experience

  • 2022-2023: Postdoctoral Research Scientist, Sir William Dunn School of Pathology, University of Oxford, United Kingdom.
  • 2010-2020: Postdoctoral Research Scientist, Department of Physiology, Anatomy and Genetics, United Kingdom. University of Oxford, United Kingdom.

Research Interest

  • ADP-Ribosylation signalling and Ca2+ signalling pathways in human diseases.
  • PARP arbitrated spatio-temporal profile of ADPR in DNA repair and oncology as well as in infection and immunity.

Publications

  • Kar P, Chatrin C, Đukić N, Suyari O, Schuller M, Zhu K, Prokhorova E, Bigot N, Ahel J, Elsborg JD, Nielsen ML, Clausen T, Huet S, Niepel M, Sanyal S, Ahel D, Smith R, Ahel I. PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation. EMBO J. 2024 Jul;43(14):2929-2953.
  • Kar P, Lin YP, Bharadwaj R, Tucker CJ, Bird GS, Hediger MA, Monico C, Amin N, Parekh AB: The N-terminus of Orai1 couples to the AKAP79 signalling complex to drive NFAT1 activation by local Ca2+ entry: PNAS (USA), 2021, 118(19), e2012908118
  • Kar P, Mirams G, Christine H, Parekh AB: Control of NFAT isoform-specific gene expression through two co-incidents and segregated Ca2+ microdomains. Molecular Cell, 2016, 64(4): 746-759.
  • Kar P, Parekh AB: Distinct spatial Ca2+ signatures selectively activate different NFAT transcription factor isoforms. Molecular Cell, 2015, 58, 232-43.
    Previews by Donald L Gill: Calcium signals tune the fidelity of transcriptional responses. Molecular Cell 58, 2015, 197-99.
  • Kar P, Samanta K, Morris O, Bakowski D, Parekh AB: Dynamic assembly of a membrane signalling complex enables selective activation of NFAT by Orai1. Current Biology, 2014, 24(12), 1361-8.
  • Đukić N, Strømland Ø, Elsborg JD, Munnur D, Zhu K, Schuller M, Chatrin C, Kar P, Duma L, Suyari O, Matthias JGR,Baretić D, Crudgington DR, Groslambert J, Fowler G, Wijngaarden S, Prokhorova E, Rehwinke J, Schüler H, Filippov VD,Sanyal S, Ahel D, Nielsen M, Smith R, Ahel I: PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities. Science Advances, 2023

Contact Details

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