Recent News

The Department of Chemistry is glad to announce that Dr Rajapandiyan Panneerselvam, Associate Professor, Ms Jayasree K, Research Scholar, and Ms Mounika Renduchintala, BSc student, have had their breakthrough research published as a patent titled “A Method for Detecting Microplastics from Contaminated Products” with Application Number: 202441045388. Various research has been undertaken by scientists in developing improved methods for sample preparation and data analysis, aiming to reliably detect pollutants like microplastics in complex samples such as sea salt, soil, and water. In line with these efforts, this patent introduces a rapid and easy method to detect microplastics in contaminated products and water bodies using a filter paper-based substrate.

Abstract

Surface-enhanced Raman spectroscopy (SERS) has emerged as one of the most promising analytical tools in recent years due to its advantageous features, such as high sensitivity, specificity, ease of operation, and rapid analysis. These attributes make SERS particularly well-suited for environmental and food analysis. However, detecting target analytes in real samples using SERS faces several challenges, including matrix interference, low analyte concentrations, sample preparation complexity, and reproducibility issues. Additionally, the chemical complexity of pollutants and environmental factors can impact SERS measurements. Overcoming these hurdles demands optimized experimental conditions, refined sample preparation methods, and advanced data analysis techniques, often necessitating interdisciplinary collaborations for effective analysis. Therefore, our focus lies in the development of various methods for fabricating SERS substrates, pretreating analytes, and devising sample preparation strategies. These efforts aim to enable the detection of analytes like microplastics within complex real samples, including sea salts, soil samples, lake water, and various food products.

Practical Implementation/ Social Implications of the Research

SERS Community: Introducing a facile fabrication method for developing filter paper-based substrates, utilizing evaporation-induced self-assembly methods with the aid of 96-well plates. These substrates boast exceptional sensitivity and uniformity, exhibiting a relative standard deviation (RSD) of 8.2%. They offer easy fabrication and serve as effective SERS substrates for various applications.

Industry and Government Bodies: This invention plays a pivotal role in assessing contamination in food and water bodies, serving as a crucial tool in monitoring environmental contamination through on-site analysis with portable instruments. It ensures adherence to regulatory standards and safeguards public health.

Research: Beyond its practical applications, the invention supports scientific research endeavors focused on identifying microplastic contaminants in real-world samples using portable Raman spectrometers. This not only aids ongoing research but also paves the way for future studies in this critical field.

Collaborations

• Dr Hemanth Noothalapati – Raman Project Center for Medical and Biological Applications, Shimane University, Japan
• Dr Murali Krishna C – Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India
• Dr Soma Venugopal – University of Hyderabad, India

The research team hopes to develop a novel SERS substrate for the detection of environmental pollutants in real-world samples.

Dr Rajapandiyan P, Associate Professor, Department of Chemistry, and his PhD scholar, Ms Arunima Jinachandran, recently filed and published a patent, “A Substrate for Contaminant Detection and a Process for its Synthesis,” with Application Number: 202441043642 in the Patent Office Journal. The research duo has developed a novel SERS (Surface-Enhanced Raman Spectroscopy) substrate by synthesising silver nanopopcorn and depositing it on a polycarbonate membrane.

This novel substrate demonstrates excellent uniformity, reproducibility, and mechanical stability. It is used for the sensitive detection of toxic antibiotic nitrofurazone on fish surfaces and in honey. This breakthrough could significantly enhance food safety monitoring by providing a reliable and efficient method for detecting harmful substances.

Abstract

Detecting nitrofurazone (NFZ) in aquaculture and livestock is crucial due to its carcinogenic properties. This study presents a flexible polycarbonate membrane (PCM) with three-dimensional silver nanopopcorns (Ag NPCs) for NFZ detection on fish surfaces using surface-enhanced Raman spectroscopy (SERS). The Ag-NPCs/PCM substrate demonstrates a significant Raman signal enhancement (EF = 2.36 × 106) due to hotspots from nanoscale protrusions and crevices. It achieves a low limit of detection (LOD) of 3.7 × 10−9 M, with uniform and reproducible signals (RSD < 8.34%) and retains 70% efficacy after 10 days. The practical detection LODs for NFZ in tap water, honey water, and on fish surfaces are 1.35 × 10−8 M, 5.76 × 10−7 M, and 3.61 × 10−8 M, respectively, demonstrating its effectiveness for various samples. This Ag-NPCs/PCM substrate offers a promising approach for sensitive SERS detection of toxic substances in real-world applications.

Practical Implementation/ Social Implications of the Research

The practical applicability of the proposed Ag-NPCs/PCM SERS substrate is validated by successfully detecting NFZ in various actual samples, such as tap water, honey water, and irregular fish surfaces.

Collaborations – Prof. Tzyy-Jiann Wang – National Taipei University of Technology, Taiwan

Dr Rajapandiyan and Ms Arunima will continue to work towards the development of novel flexible SERS substrates for detecting toxic pollutants in food.

As part of the 13th edition of the Bengaluru India Nano 2024, heralded by Bharat Ratna recipient and renowned chemist Prof. C N R Rao, SRM University-AP hosted “Nano Jatha“, an intensive science outreach programme, catering to educate undergraduate graduates on the emerging trends of nanotechnology, on July 20, 2024. The Nano Jatha programme organised, aimed to raise awareness on nanoscience and technology through technical presentations by expert scientists and a distinctive live experiment demonstration of nano kits focused on showcasing nanoscience ideas.

The event featured two expert talks by eminent dignitaries. Prof. B L V Prasad, Director-Centre for Nano and Soft Matter Sciences (CeNS), Department of Science and Technology, Govt. of India, also serving as the Nodal Officer for organising Nano Jatha events, delivered a session on the introduction to nanoscience and technology. “Nanoscience and technology are often foretold as the technology of the future. This multidimensional technology will revolutionise our understanding of every natural phenomenon and every aspect of human life,” remarked Prof. Prasad in his session.

Prof. C P Rao, Senior Professor at the Department of Chemistry, presented the second expert talk on the applications of nanomaterials. The session delved into the properties of covalent molecules and its assemblage leading to cutting-edge technology. The programme also featured an exhibition were experiments on Gold nanoparticle; Galvanization reaction between metals; Piezoelectric pavement for futuristic applications; Humidity sensors for real-world applications and many more were displayed.

Prof. C V Tomy, Dean-School of Engineering & Sciences and Dr Pardha Saradhi Maram, Head-Department of Chemistry, emphasised that the Nano Jatha exemplified the university’s commitment to hands-on learning in science, specifically nanotechnology.They commented that the Department of Chemistry is dedicated to fostering scientific knowledge and igniting passion for chemistry among students and educators alike and will continue to organise events like Nano Jatha, conferences, workshops, and Faculty Development Programmes to achieve the same.

Over 300 students from 7 regional colleges in Andhra Pradesh participated in the programme, displaying their zeal in the discussions and nano kit demonstrations. The event was well executed benefitting the student community significantly in understanding various emerging fields in science and technology.

Dr Chinmoy Das, Assistant Professor at the Department of Chemistry at SRM University-AP, has made an impactful contribution with the publication of his research paper, “Insights into the Mechanochemical Glass Formation of Zeolitic Imidazolate Frameworks” in the prestigious Angewandte Chemie International Edition with an impact factor of 16.6. His paper unveils a rapid, eco-friendly, and efficient mechanochemical approach to transform glasses from their crystalline zeolitic imidazolate frameworks. This pioneering work opens new doors for sustainable and effective glass formation, showcasing the power of innovation in the field of chemistry.

Abstract:

We describe a rapid, ecofriendly, and efficient mechanochemical approach to transform glasses from their crystalline zeolitic imidazolate frameworks (ZIFs). We exposition mechanochemical technique through which the traditional melt-quench preparation of glassy phases can be replaced. In this study, we explore that Zn(II), Co(II), and Cu(II)- based crystalline ZIFs transformed into the glassy phases within five minutes through the mechanical ball milling technique. The appearance of glass transition temperature(T g ) upon mechanical milling of crystalline states demonstrated by different characterization techniques, such as X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), simultaneous thermogravimetric and differential thermal analyses (TG/DTA), scanning electron microscopy (SEM), X-ray total scattering and its deduced pair distribution functions (PDFs). We characterized the porosity and density of the glassy phases through CO 2 gas sorption techniques which aligned with the observation of thermal, structural, and textural features of the ZIFs after varying ball milling times beyond five minutes.

Practical implementation

We can prepare bulk ZIF glasses within five minutes of the mechanochemical approach that will guide the greater feasibility to produce the glass materials for industrial implications. In addition, the greater the accessibility of glassy materials, the greater the fabrication of glassy materials-based device fabrication.

Collaborations

This article has been published with the collaboration of Prof. Sebastian Henke (Henke Group), Department of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.

Future Research Plans

Recently, we established our research group in SRM University-AP, and our group has started to explore an emergent research area of crystal-glass composite materials towards the applications of atmospheric water harvesting, solid-state electrolytes (Alkali and Alkaline metal ions-based), photovoltaics, and conversion of gaseous Carbon-dioxide molecules to industrially relevant liquids, such as methanol or ethanol.

• Figure 1. (A) Single crystal structures of various ZIFs indicated in the figure. (B) Schematic representation of the traditional route to ZIF glass formation (red line) and the mechanochemical vitrification approach followed in this work (blue line). (C) PXRD patterns of the pristine ZIF polycrystalline materials and after five minutes of mechanical ball milling.