In a significant academic achievement, the Department of Mathematics is proud to announce that Dr Koyel Chakravarty, an Assistant Professor, along with her diligent PhD Scholar, Ms Amrutha Sreekumar, has made a remarkable contribution to the field of biological mathematics. Their paper, titled “Exploring the Impact of PTH Therapy on Bone Remodeling: A Mathematical Investigation,” has been officially accepted for publication in the prestigious Journal of Biological Systems by World Scientific.

This paper presents a comprehensive mathematical model that investigates the effects of Parathyroid Hormone (PTH) therapy on bone remodelling processes. The research provides valuable insights that could potentially lead to more effective treatments for bone-related diseases and conditions.

The university community extends its heartfelt congratulations to Dr Chakravarty and Ms Sreekumar for their dedication and hard work.

Abstract

The regulatory role of parathyroid hormone (PTH) on bone, a crucial calcium reservoir, is influenced by sex steroids, notably estrogen. A mathematical model elucidates PTH-mediated bone remodeling mechanisms, examining plasma PTH effects and external dosages. Daily PTH injections, with their dual anabolic or catabolic action, offer a notable treatment for severe osteoporosis. This study predicts osteogenic responses to PTH, integrating factors like TGF-β, RANKL, and bisphosphonates in osteoblast-osteoclast signaling, alongside PTH’s effects on glands and regulatory molecules like Runx2, pCREB, and Bcl2. Using various methods, including simulations and sensitivity analysis, it aims to understand PTH therapy’s impact on bone volume, enhancing its clinical relevance.

Explanation of the Research in Layperson’s Terms

The role of parathyroid hormone (PTH) in calcium storage within bones is significant, with its regulation influenced by other hormones, notably estrogen. A mathematical model has been developed to comprehend the effects of PTH on bones, examining both endogenous levels in the blood and exogenous intake requirements. It has been observed that daily PTH injections can be beneficial in treating severe bone conditions like osteoporosis, as these injections can induce either bone formation or resorption, depending on their administration method. Additionally, the response of bones to PTH is under scrutiny in this study, considering various substances such as TGF-β, RANKL, and bisphosphonates, and their interplay in maintaining bone health. Through the utilization of different methodologies including computer simulations, efforts are being made to precisely understand how PTH injections influence bone health, thereby enhancing their efficacy in addressing bone-related ailments.

Title of the Research paper in the Citation Format

Exploring the Impact of PTH Therapy on Bone Remodeling: A Mathematical Investigation

Practical Implementation or the Social Implications Associated
Personalized Treatment Plans:
Mathematical modeling of bone remodeling can facilitate the development of personalized treatment plans for individuals with bone disorders such as osteoporosis. By considering factors like hormone levels, genetic predispositions, and lifestyle factors, healthcare providers can tailor treatment strategies to optimize bone health outcomes.
1. Drug Development:
Insights gained from mathematical models can aid in the development of new drugs for bone disorders. By simulating the effects of potential therapeutic agents on bone remodeling processes, researchers can identify promising candidates for further investigation, potentially accelerating the drug discovery process.
2. Improved Clinical Decision Making:
Healthcare professionals can use mathematical models to make more informed clinical decisions regarding the management of bone disorders. By integrating patient-specific data into predictive models, clinicians can better predict treatment outcomes and adjust therapeutic interventions accordingly.
3. Enhanced Surgical Planning:
Mathematical modeling can also be valuable in surgical planning for procedures such as bone grafting or joint replacement. By simulating the effects of surgical interventions on bone remodeling, surgeons can optimize surgical techniques to promote more effective healing and long-term outcomes for patients.
4. Public Health Interventions:
Understanding the factors influencing bone remodeling at a population level can inform public health interventions aimed at reducing the burden of bone disorders. By identifying modifiable risk factors and developing targeted prevention strategies, policymakers can promote bone health and reduce the incidence of conditions like osteoporosis on a larger scale.
5. Educational Tools:
Mathematical models of bone remodeling can serve as educational tools for healthcare professionals, students, and patients. By visualizing complex biological processes in a simplified manner, these models can enhance understanding of bone physiology and the mechanisms underlying bone disorders, ultimately improving patient care and outcomes.

Collaborators:
• Prof. D.C. Dalal, Professor, Department of Mathematics, IIT Guwahati
• Dr. L.N. Guin, Associate Professor, Department of Mathematics, Visva-Bharati

Future research plans.
a) Incorporating Multi-Scale Modeling: Future research could focus on integrating multi-scale modeling approaches to capture the intricate interactions occurring at different levels of bone structure, from the molecular to the tissue level. By incorporating information on cellular processes, tissue mechanics, and systemic factors, these models could provide a more comprehensive understanding of bone remodeling dynamics.
b) Accounting for Heterogeneity: There is a need to develop mathematical models that account for the heterogeneity observed in bone remodeling processes across individuals and within different anatomical sites. By considering factors such as age, sex, genetics, and bone quality, researchers can create more personalized and accurate models to predict individual responses to treatment and disease progression.
c) Integration of Advanced Imaging Techniques: Advances in imaging technologies such as micro-computed tomography (micro-CT) and magnetic resonance imaging (MRI) provide detailed insights into bone structure and function. Future research could focus on integrating data from these advanced imaging techniques into mathematical models to enhance their predictive capabilities and enable non-invasive monitoring of bone remodeling in clinical settings.
d) Exploring Therapeutic Interventions: Researchers could use mathematical modeling to explore the efficacy of novel therapeutic interventions for bone disorders, such as drug treatments, exercise regimens, and dietary interventions. By simulating the effects of these interventions on bone remodeling processes, researchers can identify optimal treatment strategies and accelerate the development of new therapies.

Pictures Related to the Research

Link to the article

DOI: https://doi.org/10.1142/S021833902450027X

The Department of Civil Engineering is thrilled to host Er. Lakhwant Singh Khalsa for its 3rd Industry Guest Lecture Series. Mr Khalsa, Project Manager at Systra India, Haryana, will deliberate on “Railway Bridges and Track Structure – Practitioner Perspectives”. His lecture will offer deep insights into Railway Track Structure and Components and Railway Bridge Elements and Bridge Types. We Invite all civil engineering students and enthusiasts to join the insightful session on April 23, 2024.

About the Speaker:

Er. Lakhwant Singh Khalsa currently working as a project manager, Systra/PMC for RVNL Vijayawada 3rd line rail project. He has 41 years of rich & extensive experience in railway steel bridge structures, civil bridge works and project management. He is a Life Member of the Institution of Permanent Way Engineers (India)-IPWE and the Indian Institution of Bridge Engineers-IIBE. He holds several prestigious certifications, such as welding inspector from the welding research institute BHEL Trichy and Level II Certification in Non-Destructing Testing for DPT, MPT & UT as per SNT TC IA2006. He is familiar with IS, IRS, EN, and BS Codes, which are relevant to steel and concrete works. Also, he has experience working in hilly terrains in the Himalayan Ranges with critical environmental conditions.

Dr Ramesh Vaddi, and Dr Siva Sankara Yelampalli, Assistant Professors at the Department of Electronics and Communication Engineering, along with research scholars Mr Birudu Venu, Mr Tirumala Rao Kadiyam, and Mr Koteswara Rao Penumalli, have jointly published a paper titled “Computing in-memory reconfigurable (accurate/approximate) adder design with negative capacitance FET 6T-SRAM for energy efficient AI edge devices” The paper introduces Computing in-memory (CiM) as a promising alternative to traditional von-Neumann architectures, focusing on its potential for energy-efficient AI edge computing with CMOS scaling. Additionally, they have explored the advancements in approximate computing in-memory (ACiM) techniques, aiming to further enhance the energy efficiency of these innovative architectures.

Abstract:

Computing in-memory (CiM) is an alternative to von Neumann architectures for energy-efficient AI edge computing architectures with CMOS scaling. Approximate computing in-memory (ACiM) techniques have also been recently proposed to further increase the energy efficiency of such architectures. In the first part of the work, a negative capacitance FET (NCFET) based 6T-SRAM CiM accurate full adder has been proposed, designed and performance benchmarked with equivalent baseline 40 nm CMOS design. Due to the steep slope characteristics of NCFET, at an increased ferroelectric layer thickness, Tfe of 3 nm, the energy consumption of the proposed accurate NCFET-based CiM design is ∼82.48% lower in comparison to the conventional/Non CiM full adder design and ∼85.27% lower energy consumption in comparison to the equivalent baseline CMOS CiM accurate full adder design at VDD = 0.5 V. This work further proposes a reconfigurable computing in-memory NCFET 6T-SRAM full adder design (the design which can operate both in accurate and approximate modes of operation). NCFET 6T-SRAM reconfigurable full adder design in accurate mode has ∼4.19x lower energy consumption and ∼4.47x lower energy consumption in approximation mode when compared to the baseline 40 nm CMOS design at VDD = 0.5 V, making NCFET-based approximate CiM adder designs preferable for energy efficient AI edge CiM based computing architectures for DNN processing.

Future research plans: Implementing reconfigurable computing in-memory (CiM) MAC for energy-efficient AI edge devices.

Link to the article

The Department of Economics is thrilled to announce the publication of Assistant Professor Dr Ghanshyam Kumar Pandey’s research paper titled, “Bifurcation and Agricultural Development in Jharkhand,” in Economic and Political Weekly. The paper delves into the developmental trajectory of Jharkhand following its bifurcation from Bihar in 2000 and examines the intricacies of agricultural development and the key determinants that have shaped its evolution post-separation.

Abstract:

The cropping pattern in Jharkhand has significantly changed from 2000 to 2016, with shifts from the cultivation of cereals to non-cereals. An increase in the crop area and diversification towards high-value crops have accelerated overall agricultural growth. Capital formation and better infrastructure facilities, along with improved fertiliser consumption and irrigation, will foster agricultural development in Jharkhand

Practical implementation:

This study shows the development path of Jharkhand after bifurcation from Bihar in 2000. The study deals with the process of agricultural development and determinants of agricultural development after its bifurcation.

Link to the article

The Department of Physics is thrilled to announce a remarkable milestone in sustainable technology. Dr Sabyasachi Mukhopadhyay, Associate Professor and Ms Sreelekha Bhuvaneswari, BSc student has been officially granted a patent for their groundbreaking invention: “A fibre material with moisture retention capacity with thermal tolerance and a method for manufacture of the same.”

This pioneering material, distinguished by its Application Number 202141023375, stands at the forefront of cooling technology. It promises to enhance thermal regulation while prioritising environmental sustainability.

Dr Mukhopadhyay’s invention is poised to make significant contributions to the field of material science, offering a versatile solution that holds potential applications across various industries. The department extends its heartfelt congratulations to the duo on this significant achievement and looks forward to the positive impact his work will continue to have on our community and beyond.

Abstract:

The project, with the patent application number 202141023375, develops a methodology to design a fabric cloth that would replace the use of air conditioners. This cloth design is inspired by Saharan silver ants which regulate their body temperatures in the scorching desert heat and also from the cooling properties of clay. This research would significantly scale down the usage of AC and other cooling devices in warm places, thus reducing the use of electricity and emission of greenhouse gases to the environment. As this cloth would be environment friendly with long durability and cost-efficiency, Sreelekha hopes that this research would bridge the socioeconomic divide of haves and have-nots between communities.

Explanation of the Research in Layperson’s Terms :

Using room conditioning AC during these times, especially with lower temperatures is very risky. Virus spread with closed circulated air or prolonged cold temperatures while breathing, so thus using air conditioning is bad. With this in mind, we need an efficient way of cooling in the snoring temperatures. We propose developing a fabric that integrates clay (Its primary mineral is kaolinite; clay may be generally described as 40% aluminium oxide, 46% silicon oxide, and 14% water.) in its synthesis; clay is known for its cooling properties given enough water to retail and proper reflection techniques for heat throughout the fabric inspired from uniquely shaped hairs with triangular cross-sections as in arrangement employed by the Saharan silver ants. This model not only conserves energy compared to room cooling but also is very practical, wherein we can dampen the fabric with the least water and retain its cooling for long hours. This Fabric could be employed in a variety of settings, for example, in making carpets and curtains in a house to keep the room temperature regulated.

Practical Implementation and Social Implications:

The research would significantly scale down the usage of AC and other cooling devices in warm places, thus reducing the use of electricity and emission of greenhouse gases to the environment. As this cloth would be environment friendly with long durability and cost-efficiency, Sreelekha hopes that this research would bridge the socioeconomic divide of haves and have-nots between communities.

The Title of Patent in the Citation Format

“A fibre material with moisture retention capacity with thermal tolerance and a method for manufacture of the same” with Application Number: 202141023375

Collaborations:

Prof. Seeram Ramakrishna, Professor of Materials, National University of Singapore

Future Research Plans:

The forthcoming endeavour encompasses the commercialisation of this pioneering concept to render it widely accessible and applicable on a larger scale.

“The very idea of a platform such as this is to promote multidisciplinary collaborative research,” emphasised Prof. K Hemachandra Reddy, Chairman, Andhra Pradesh State Council of Higher Education (APSCHE), encapsulating the spirit of the 1st Research Scholar’s Summit hosted at SRM University-AP in partnership with the Government of Andhra Pradesh. The event was staged to reinforce research within academic circles and herald a new phase of learning. The summit was attended by esteemed dignitaries like Prof. Korukonda Babji, Vice Chancellor Dr Y S R University of Health Sciences; Prof. Ramesh Srikonda, Director-School of Planning and Architecture; Dr M Balakrishnan, IIT, Delhi, along with Vice Chancellor, Prof. Manoj K Arora; Registrar, Dr R Premkumar, Deans, Faculty, and Students.

In his keynote address, Vice Chancellor Prof. Arora emphasised the pivotal role of such summits in fostering a conducive environment. He stated, “We live in a world of collaborations, and a summit like this gives an opportunity to interact, establish partnerships and forge scholarly excellence”. He highlighted the varsity’s research acumen in the form of patents, technology transfers, research publications, start-ups, and incubations. He also declared that the varsity would be open to sharing its state-of-the-art research infrastructure among the broader demography in order to foster a research mindset among all.

Prof. Ranjit Thapa, Dean-Research at the university, highlighted the participation of 150 PhD scholars from diverse institutions. His speech reflected the tireless commitment to building the university’s scientific fortitude. Prof. Srikonda underscored the significance of technological advancement and innovation. He praised the summit for being a stage that will offer pragmatic solutions to societal challenges and commended its tagline – “Inspire, Ignite, Innovate,” for aligning with its core objectives.

Prof. Korukonda Babji and Prof. M Balakrishnan, pivotal figures in academia, articulated the transformative role of cutting-edge research in elevating society. They emphasised the potential of such forums in catalysing groundbreaking changes in research.

The summit showcased presentations from doctoral scholars, encompassing 60 poster presentations and 90 oral presentations, organised across 8 thematic areas. The summit concluded with a valedictory function, and tokens of appreciation were presented to the dignitaries by the Vice Chancellor, Registrar, Deans, and convenors, Dr Ramanjaneya Reddy and Dr Sabyasachi Chakrabortty, and members of the organising committee.

Dr Banee Bandana Das,  Assistant Professor in the Department of Computer Science and Engineering, has achieved a remarkable milestone. The invention titled “An Energy Harvesting System for Node Devices and a Method Thereof” has been granted a patent by the Patent Office Journal, under Application Number: 202241066526. This achievement marks a significant leap forward in the realm of energy harvesting systems, promising a brighter and more secure future for IoT applications.

Abstract

The present invention is broadly related to design of secure and Trojan Resilient energy harvesting system (EHS) for IoT end node devices. The objective is to develop a state-of-the-art energy harvesting system which can supply uninterrupted power to the sensors used in IoT. The EHS is self-sustainable. The higher bias voltages are generated on chip. The system is mainly consisting of security module, power conditioning module, Trojan Resilient module, and load controller module. The power failure of the sensors used in IoT may leads to information loss thereby causing catastrophic situations. An uninterrupted power supply is a must for smooth functioning of the devices in IoT. This invention caters secure power requirements with security issues of IoT end node devices.

Practical Implementation:

The IoT end node devices needs 24*7 power supply and are very sensitive to attacks made by adversaries before and after fabrication. This invention takes care of the power requirement of end node devices with green energy and secure the EHS-IC from adversaries and attacks and therefore can be used by individuals, as powering sensors at remote locations and as part of smart agriculture.

Future research plans:

Design more secure and reliable design for making a IoT smart node smarter and self-Sustainable. Exploring more circuit level techniques and find new way to design more power efficient designs.

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