Rs. 44 lacs fund from SERB-DST for functionalized alkene preparation strategy

Prof S Mannathan has added SRM University-AP to the list of those research-oriented Universities which try to direct their research to make the world a better place. With this new SERB-DST project of Rs. 44 lacs fund, Dr Mannathan and his team will be able to investigate into developing a strategy to prepare functionalized alkenes in a manner that is pro-environment and industrially economic.

Why functionalized alkenes? Alkene is a hydrocarbon with a C=C bond. It is readily available and a fan favourite among chemists. It reacts favourably with a variety of reactants and is a preference in the synthesis of bioactive compounds. This procedure aids in the preparation of several valuable compounds with a variety of uses from the manufacturing of antidepressants to the treatment of cancer.

What Prof Mannathan says about the project:

“We intend to develop a highly efficient, low-cost, environmentally-friendly strategy to prepare functionalized alkenes in a highly regio- and stereoselective manner. A step- and atom economic reductive coupling strategy will be employed by using a photoredox and a low valent metal dual catalyst to prepare such molecules. This novel approach avoids the use of any external reducing agent and generates the low valent metal species in situ using a photocatalyst.”

Dr Mannathan was granted a total of Rs. 44,11,264 for a period of 3 years. Dr Mannathan believes that with a SERB sanctioned fund of Rs. 44 lacs, he and his team will be able to design a new and revolutionary protocol. The newly designed protocol could be useful in the synthesis of various biologically active molecules and natural products such as aigialomycin D which is a helpful compound in inhibiting protein kinases that are related to cancer pathways.

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