Assistant Professor

Dr Yenuganti Vengala Rao

Department of Biological Sciences

Interests

  • Understanding of biology of extracellular vesicles derived from natural sources like milk, probiotic bacteria and plants fruits
  • Engineering of extracellular vesicles by biochemical and biotechnological tools

Faculty Details

Education

2005

Sri Krishnadevaraya University, Anantapur,
Andhra Pradesh, India.
B.Sc.

2009

National Dairy Research Institute,
Karanal, Haryana,
India.
M.Sc.

2014

National Dairy Research Institute, Karanal,
Haryana, India.
Ph.D.

Experience

  • 2014-2016- Scientist- Leibniz Institute for Farm Animal Biology, Germany
  • 2017-2023- DST- INSPIRE Faculty- University of Hyderabad, India
  • 2023-2024- SERB Research Scientist - University of Hyderabad, India

Research Interest

  • Our lab is interested in investigating the role of milk, probiotic and fruits derived extracellular vesicles on bacterial, intestinal epithelial, and immune cells. In this direction, we are investigating how milk-derived extracellular vesicles influence the microbial and immune cell populations in the gastrointestinal tract
  • We are working on improving and simplifying milk extracellular vesicles isolation processes. Furthermore, we are also working on separation, characterization, and elucidating the functional features of plant-derived extracellular vesicles, as well as engineering of hybrid extracellular vesicles.
  • Bioengineering of extracellular vesicles derived from natural sources to enhance target-specific delivery of various pharmacological molecules, miRNAs, and proteins

Awards & Fellowships

  • 2012- UGC JRF- CSIR-UGC
  • 2017- DST-INSPIRE Faculty- Department of Science and Technology, Govt. of India
  • 2017-SERB National Post Doctral Fellowship (Not aviled)- SERB, Govt. of India
  • 2023- SERB Research Scientist- SERB, Govt. of India

Memberships

  • Senior member of International Society for Extracellular Vesicles
  • Member of Indian Extracellular Vesicles Society

Publications

  1. Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q. L., Hill, A. F., Lenassi, M., Lim, S. K., Mahoney, M. G., Mohanty, S., Möller, A., Nieuwland, R., Ochiya, T., … Witwer, K. W. (2024). Minimal information for studies of extracellular vesicles (MISEV2023) Part of MISEV2023: From basic to advanced approaches. Journal of extracellular vesicles, 13(2), e12404. https://doi.org/10.1002/jev2.12404
  2. Yenuganti, V. R., Afroz, S., Khan, R. A., Bharadwaj, C., Nabariya, D. K., Nayak, N., Subbiah, M., Chintala, K., Banerjee, S., Reddanna, P., & Khan, N. (2022). Milk exosomes elicit a potent anti-viral activity against dengue virus. Journal of nanobiotechnology, 20(1), 317. https://doi.org/10.1186/s12951-022-01496-5
  3. Manukonda, R., Yenuganti, V. R., Nagar, N., Dholaniya, P. S., Malpotra, S., Attem, J., Reddy, M. M., Jakati, S., Mishra, D. K., Reddanna, P., Poluri, K. M., Vemuganti, G. K., & Kaliki, S. (2022). Comprehensive Analysis of Serum Small Extracellular Vesicles-Derived Coding and Non-Coding RNAs from Retinoblastoma Patients for Identifying Regulatory Interactions. Cancers, 14(17), 4179. https://doi.org/10.3390/cancers14174179
  4. Ahmed, F., Tamma, M., Pathigadapa, U., Reddanna, P., & Yenuganti, V. R. (2022). Drug Loading and Functional Efficacy of Cow, Buffalo, and Goat Milk-Derived Exosomes: A Comparative Study. Molecular pharmaceutics, 19(3), 763–774. https://doi.org/10.1021/acs.molpharmaceut.1c00182
  5. Manukonda, R., Attem, J., Yenuganti, V. R., Kaliki, S., & Vemuganti, G. K. (2022). Exosomes in the visual system: New avenues in ocular diseases. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 44(1), 129–152. https://doi.org/10.3233/TUB-211543
  6. Yenuganti, V. R., Yadala, R., Azad, R., Singh, S., Chiluka, V., Ahire, J., & Reddanna, P. (2021). In vitro evaluation of anticancer effects of different probiotic strains on HCT-116 cell line. Journal of applied microbiology, 131(4), 1958–1969. https://doi.org/10.1111/jam.15060
  7. Yenuganti, V. R., Koczan, D., & Vanselow, J. (2021). Genome wide effects of oleic acid on cultured bovine granulosa cells: evidence for the activation of pathways favoring folliculo-luteal transition. BMC genomics, 22(1), 486. https://doi.org/10.1186/s12864-021-07817-6
  8. Nabariya, D. K., Pallu, R., & Yenuganti, V. R. (2020). Exosomes: The protagonists in the tale of colorectal cancer?. Biochimica et biophysica acta. Reviews on cancer, 1874(2), 188426. https://doi.org/10.1016/j.bbcan.2020.188426
  9. Yenuganti, V. R., Ravinder, & Singh, D. (2017). Endotoxin induced TLR4 signaling downregulates CYP19A1 expression through CEBPB in buffalo granulosa cells. Toxicology in vitro : an international journal published in association with BIBRA, 42, 93–100. https://doi.org/10.1016/j.tiv.2017.04.012
  10. Rani, P., Yenuganti, V. R., Shandilya, S., Onteru, S. K., & Singh, D. (2017). miRNAs: The hidden bioactive component of milk. Trends in Food Science & Technology, 65, 94-102. https://doi.org/10.1016/j.tifs.2017.05.007
  11. Yenuganti, V. R., & Vanselow, J. (2017). Oleic acid induces down-regulation of the granulosa cell identity marker FOXL2, and up-regulation of the Sertoli cell marker SOX9 in bovine granulosa cells. Reproductive biology and endocrinology: RB&E, 15(1), 57. https://doi.org/10.1186/s12958-017-0276-zY
  12. Yenuganti, V. R., Viergutz, T., & Vanselow, J. (2016). Oleic acid induces specific alterations in the morphology, gene expression and steroid hormone production of cultured bovine granulosa cells. General and comparative endocrinology, 232, 134–144. https://doi.org/10.1016/j.ygcen.2016.04.020
  13. Yenuganti, V. R., & Vanselow, J. (2017). Cultured bovine granulosa cells rapidly lose important features of their identity and functionality but partially recover under long-term culture conditions. Cell and tissue research, 368(2), 397–403. https://doi.org/10.1007/s00441-017-2571-6
  14. Yenuganti, V. R., Baddela, V. S., Baufeld, A., Singh, D., & Vanselow, J. (2015). The gene expression pattern induced by high plating density in cultured bovine and buffalo granulosa cells might be regulated by specific miRNA species. The Journal of reproduction and development, 61(2), 154–160. https://doi.org/10.1262/jrd.2014-119
  15. Baddela, V. S., Baufeld, A., Yenuganti, V. R., Vanselow, J., & Singh, D. (2014). Suitable housekeeping genes for normalization of transcript abundance analysis by real-time RT-PCR in cultured bovine granulosa cells during hypoxia and differential cell plating density. Reproductive biology and endocrinology : RB&E, 12, 118. https://doi.org/10.1186/1477-7827-12-118
  16. Yenuganti, V. R., Ravinder, R., & Singh, D. (2014). Conjugated linoleic acids attenuate LPS-induced pro-inflammatory gene expression by inhibiting the NF-κB translocation through PPARγ in buffalo granulosa cells. American journal of reproductive immunology (New York, N.Y. : 1989), 72(3), 296–304. https://doi.org/10.1111/aji.12261
  17. Reddy, B. M., Reddy, M. C., Yenuganti, V. R., Reddy, G. V., & Reddanna, P. (2017). Purification and Characterization of LTC 4 Synthase from Sheep Uterus. Journal of Endocrinology and Reproduction, 35-42.
  1. Pothuraju, R., Yenuganti, V.R., Hussain, S.A., Sharma, M. Chapter 29—Fermented Milk in Protection Against Inflammatory Mechanisms in Obesity. In Immunity and Inflammation in Health and Disease; İçinde, S., Chatterjee, W., Jungraithmayr, D.B., Eds.; Academic Press: Cambridge, MA, USA, 2018; pp. 389–401. https://doi.org/10.1016/B978-0-12-805417-8.00029-9

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