Research articles

• 1. Evolution of Human-specific Alleles Protecting Cognitive Function of Grandmothers - S. Saha, N. Khan, A. Verhagen, A. Sasmal, T. Comi, S. Diaz, H. Yu, X. Chen, J. Akey, M. Frank, P. Gagneux, A. Varki Molecular Biology and Evolution, 39 (8), (2022).
• 2. Models of murine vaginal colonization by anaerobically grown bacteria – S. Morrill, K. Agarwal, S. Saha, W. Lewis, N. Gilbert, A. Lewis Journal of Visualized Experiments,(183) (2022).
• 3. The basal complex: the other apicomplexan business end as assessed in T. gondii – M.-J. Gubbels, D.J.P. Ferguson, S. Saha, J. Romano, S. Chavan, V.A. Primo, C. Michaud, I. Coppens, K. Engelberg Frontiers in Cellular and Infectious Microbiology, 12:882166, (2022).
• 4. Evolutionary Conservation of Ketodeoxynonulosonic acid production by human cells: Humans is Not for Sialoglycan Biosynthesis – K. Kawanishi*, S. Saha*, S. Diaz, M.Vaill, A. Sasmal, S.S. Siddiqui, B. Choudhury, K. Sharma, X. Chen, I.C. Schoenhofen, C. Sato, K. Kitajima, H.H. Freeze, A. Münster-Kühnel, A. Varki The Journal of Clinical Investigation, 131(5), e137681 (2021).
• 5. Exploring the impact of ketodeoxynonulosonic acid in host-pathogen interactions using uptake and surface display by non-typeable Haemophilus influenzae – S. Saha, A. Coady, A. Sasmal, K. Kawanishi, B. Choudhury, H. Yu, R.-U. Sorensen, J. Inostroza, I.C.Schoenhofen, X. Chen, A. Münster-Kühnel, C. Sato, K. Kitajima, S. Ram, V. Nizet, A.Varki mBio, 12 (1): e03226-20 (2021).
• 6. Efficacy of anti-gonococcal CMP-nonulosonate therapeutics require cathelicidins – S. Gulati, I.C. Schoenhofen, T. Lindhout-Djukic, L.A. Lewis, I.Y. Moustafa, S. Saha, B. Zheng, N. Nowak, P.R. Rice, A. Varki, S. Ram The Journal of Infectious Diseases, 222 (10), 1641–1650 (2020).
• 7. Therapeutic CMP-nonulosonates against multidrug-resistant Neisseria gonorrhoeae – S.Gulati,I. Schoenhofen, T. Lindhout-Djukic, M. Schur, C.S. Landig, S. Saha, L. Deng, L.A. Lewis, B. Zheng, A. Varki, S. Ram The Journal of Immunology, 204 (12), 3283–3295 (2020).
• 8. Controversies about the subcellular localization and mechanisms of action of the Alzheimer’s disease protective CD33 splice variant – S. Saha, S. Siddiqui, N. Khan, A. Verhagen, W. Jiang, S. Springer, P. Ghosh, A. Varki Acta Neuropathologica 138 (4), 671-672 (2019).
• 9. Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells – J.J. Fong, C.-M. Tsai, S. Saha, V. Nizet, A. Varki, J.D. Bui Proceedings of the National Academy of Sciences, 115 (41), 10410-10415 (2018).
• 10. A member of the ferlin calcium sensor family is essential for Toxoplasma gondii rhoptry secretion – B.I. Coleman*, S. Saha*, S. Sato, K. Engelberg, D.J.P. Ferguson, I. Coppens, M.B. Lodoen, M.-J. Gubbels mBio, 9(5), e01510-18 (2018).
• 11. A novel sialylation site on Neisseria gonorrhoeae lipooligosaccharide links heptose II lactose expression with pathogenicity – S. Ram, S. Gulati, L.A. Lewis, S. Chakraborti, B. Zheng, R.B. DeOliveira, G.W. Reed, A.W. Cox, J. Li, F.S. Michael, J. Stupak, X.-H. Su, S. Saha, C.S. Landig, A. Varki, P.A. Rice Infection and Immunity 86(8): e00285-18 (2018).
• 12. Two phosphoglucomutase paralogs facilitate ionophore-triggered secretion of the Toxoplasma micronemes – S. Saha, B.I. Coleman, R. Dubey, I.J. Blader, M.-J. Gubbels mSphere, 2(6) (2017).
• 13. Parasite calcineurin regulates host cell recognition and attachment by apicomplexans – A. Paul, S. Saha, K. Engelberg, R.Y. Jiang, B.I. Coleman, A.L. Kosber, C.-T. Chen, M. Ganter, N. Espy, T.W. Gilberger, M.-J. Gubbels, M.T. Duraisingh Cell Host and Microbe, 18(1):49-60 (2015).

* Equal contribution

Conference abstracts

• 1. Deciphering the functional implication of Gardnerella sialidase activity in host interactions using isogenic bacterial strains – S. Saha, C. Armstrong, L.S. Robinson., W.G. Lewis, A.L. Lewis Glycobiology, 32 (11), 1052-1052 (2022).
• 2. Functional variation of Gardnerella sialidase NanH3 is mediated by a 5’ polycytosinetract – L.S. Robinson, S. Saha, W. Lewis, A. Lewis Glycobiology, 31(12), 1679-1679 (2021).
• 3. Understanding human-specific evolution of CD33/Siglec-3 and its impact on sialoglycan binding and functionality – S. Saha, N. Khan, A. Verhagen, A. Sasmal, H. Yu, P. Gagneux, X. Chen, N. Varki, M. Frank, A. Varki Glycobiology, 30 (12), 1016–1145 (2020).
• 4. Exploring Evolutionary Origins of Human-Specific CD33/Siglec-3 Alleles that Protect against Late Onset Alzheimer’s Disease: Prior Selection by Uniquely Human Pathogens? S. Saha, N. Khan, A. Verhagen, A. Sasmal, H. Yu, P. Gagneux, X. Chen, N. Varki, M. Frank, A. Varki Glycobiology, 29 (12), 886–989 (2019).
• 5. Exploiting the molecular mimicry of Non-typeable Haemophilus influenzae with ketodeoxynonulosonic acid: Confusing the bacterium in its own game – S. Saha, A.Coady, B. Choudhury, X. Chen, S. Ram, V. Nizet, A. Varki The Journal of Immunology, 202 (1 Supplement) 190.46 (2019).
• 6. Kdn, a Free Sialic Acid in Humans has Therapeutic Potential Against Non-Typeable Haemophilus influenzae (NTHi) infections – S. Saha, S. Diaz, B. Choudhury, S. Thiel, V. Nizet, S. Ram, I. Schoenhofen, A. Varki Glycobiology, 27 (12), 1171–1255 (2017).
• 7. Exocytosis of Toxoplasma gondii microneme and rhoptry organelles is controlled by the ferlin family of Ca 2+- sensors – B.I. Coleman, S. Saha, E.C. Gray, D. Tagoe, M.-J. Gubbels Molecular Biology of the Cell, 27 (1) (2016).
• 8. Dissecting the role of parafusin-related protein1 and calcineurin in Ca 2+ signaling of Toxoplasma gondii – S. Saha, B.I. Coleman, C.-T. Chen, M.-J. Gubbels Molecular Biology of the Cell, 25 (1), (2014).

Selected Oral Presentation

• 1. Exploring Evolutionary Origins of Human-Specific CD33/Siglec-3 Alleles that Protect against Late Onset Alzheimer’s Disease: Prior Selection by Uniquely Human Pathogens? Society for Glycobiology Annual Meeting, 2019.
• 2. Using the free nonulosonic acid Kdn as a potential therapeutic against Non-typeable Haemophilus influenzae (NTHi) infections. Future GlycoGen Meeting, 2018.
• 3. A Toxoplasma ferlin confers Ca 2+ -regulation to rhoptry secretion. XXVIIth Molecular Parasitology Meeting, 2016.
• 4. Uncovering surprising roles for calmodulin, calcineurin and PRP1 in Ca 2+ signaling underlying Toxoplasma gondii invasion and egress. XXVIth Molecular Parasitology Meeting, 2015.
• 5. Deciphering the roles of calcineurin, calmodulin and PRP1 in Ca 2+ signalling associated with Toxoplasma gondii invasion and egress. 13th International Congress on Toxoplasmosis & T. gondii Biology, 2015.
• 6. Understanding the roles of calcineurin/calmodulin/PRP1 in different Ca 2+ signalling steps related to Toxoplasma gondii invasion and egress. Annual Meeting New England Association of Parasitologists, 2015.

Selected Poster Presentation

• 1. Society for Glycobiology Annual Meeting 2022.
• 2. Society for Glycobiology Annual Meeting 2021.
• 3. Society for Glycobiology Annual Meeting 2020.
• 4. Society for Glycobiology Annual Meeting 2019.
• 5. 103rd Annual Meeting of the American Association of Immunologists (AAI), 2019.
• 6. NextGen Meeting, 22nd Annual San Diego Glycobiology Symposium, 2019.
• 7. NHLBI Programs of Excellence in Glycosciences meeting, 2018.
• 8. 21st Annual San Diego Glycobiology Symposium, 2018.
• 9. Society for Glycobiology Annual Meeting, 2017.
• 10. Smith Family New Investigator Awards Program Poster Session and Dinner, 2015.
• 11. General Meeting of the American Society for Cell Biology, 2014.
• 12. XXIVth Molecular Parasitology Meeting, 2013.