Professor

Dr. Subhabrata Sen

Department of Chemistry

Interests

  1. Synthetic Organic Chemistry
  2. Molecular Library Design
  3. Medicinal Chemistry

Education

1994

Narendrapur Ramakrishna Mission Residential College, Calcutta University
India
Bachelors

1996

Kalyani University
India
Masters

2001

University of Missouri-Columbia
India
Ph.D.

Experience

  • 08/2018 – Present, Professor | Department of Chemistry, SRM University, AP
  • 07/2016 – 07/2018, Associate Professor and Head | Department of Chemistry, Shiv Nadar University
  • 02/2013 – 06/2016, Associate Professor | Shiv Nadar University
  • 03/2010 – 12/2012, Associate Director | GVK Bioscience Hyderabad, TE, India
  • 02/2009 – 02/2010, Principal Scientist | Jubilant Chemsys, Noida, UP, India
  • 02/2008 – 01/2009, Senior Manager | Pfizer VMPS, Mumbai, India
  • 03/2006 – 01/2008, Senior Scientist | BASF-India, Mumbai India
  • 04/2004 – 02/2006, Scientific manager | Syngene International Private Limited, Bangalore, India
  • 09/2002 – 03/2006, Scientist-1 | Chemocentryx Inc., Mountain View, California
  • 06/2001 – 08/2002, Research Scientist | Prof. Albert I Meyers, Department of Chemistry, Colorado State Fort Collins, Ft. Collins, CO, USA

Research Interest

  • Development of organo- and metal catalysed strategies to access bioactive heterocycles
  • Development of diverse asymmetric strategies to synthesize 3-dimentional molecules
  • Target based discovery research in:
    • Malaria (first in class targets)
    • Type II diabetes (a-glucosidase)
    • Cancer (indoleamine-2, 3-dioxygenase and tubulin)

Research Interests ( Mentoring detail)

  • Completed PhD: Advisor: 3; Co-Advisor: 4
  • Ongoing PhD: Advisor: 3; Co-Advisor: 1

Awards & Fellowships

  • 2003: “Make it Happen” Award: Chemocentryx Inc., Mt. View, California, USA
  • Department of Science and Technology Travel Grant-2015
  • 2016: Seibold-Collegium Fellowship, Seibold Collegium Institute of Advances Studies, Julius-Maxmillians-Universität Würzburg, Würzburg, Germany

Publications

Publications and Patents 
  • Pratip K Dutta, Mahesh Kumar Ravva, Subhabrata Sen*, Cobalt catalysed, hydroxyl assisted C-H bond functionalization: Access to diversely substituted polycyclic pyrans, J. Org. Chem. 2019, doi: 10.1021/acs.joc.8b02446
  • Kunal Kumar Jha, Sanjay Dutta, Saibal Sar, Subhabrata Sen and Parthapratim Munshi*, Harnessing sun for catalyst and sensitize free regio- and stereo-selective [2+2] cycloaddition, Tetrahedron, 2018, doi: 10.1016/j.tet.2018.10.065
  • Jyoti Chauhan, Moumita Dasgupta, Tania Luthra, Akanksha Awasthi, Sayantan Tripathy, Anindyajit Banerjee, Santunu Paul, Debashish Nag, Saikat Chakrabarti, Gopal Chakrabarti and Subhabrata Sen*, Design, synthesis and biological evaluation of a novel library of antimitotic C2-aroyl/arylimino tryptamine derivatives that are also potent inhibitors of indoleamine-2, 3-dioxygenase (IDO), European Journal of Pharmaceutical Chemistry, 2018, doi:10.1016/j.ejps.2018.08.033
  • Tania Luthra, K. Naga Lalitha, A. Uma  and Subhabrata Sen*, Design, synthesis and in vitro study of densely functionalized oxindoles as potent -glucosidase inhibitors. Just accepted, Bioorganic and Medicinal Chemistry, 2018, doi.org/10.1016/j.bmc.2018.08.022
  • Pratip Dutta and Subhabrata Sen*, (Benz)Imidazole directed cobalt (III) catalysed C-H activation of Arenes: A facile strategy to access polyheteroarenes via oxidative annulation. Just Accepted, European Journal of Organic Chemistry, 2018, doi: 10.1002/ejoc.201801056.
  • Jyoti Chauhan, Tania Luthra and Subhabrata Sen*, An iodine catalyzed metal free oxidative ring opening of 1-aryltetrahydro--carbolines: Facile synthesis of C2 aroyl and aryl methanimino indole derivatives. European Journal of Organic Chemistry, 2018, 10.1002/ejoc.201800879
  • Pratip Dutta, Basabbijayi Dhar and Subhabrata Sen*, Aerobic oxidative amidation of alkynes using titanium oxide encapsulated cuprous iodide nanoparticles (CuI@TiO2). New Journal of Chemistry, 2018, 42, 12062
  • Chandramohan Bathula, Catarina Roma-Rodrigues, Jyoti Chauhan, Alexandra R. Fernandes* and Subhabrata Sen*, Synthesis of tetrahydro-1H-indolo[2, 3-b]pyrrolo[3, 2-c]quinolones via intramolecular oxidative ring rearrangement of tetrahydro-b-carbolines and their biological evaluation. New Journal of Chemistry, 2018, DOI: 10.1039/C7NJ04616B.
  • Pratip K. Dutta, Subhabrata Sen,* Debasree Saha* and Basabbijayi Dhar, Solid Supported nano structured Cu-Catalyst for solvent/ligand free C2 Amination of Azoles, Eur. J. Org. Chem. 2017, DOI: 10.1002/ejoc.201701669.
  • Jyoti Chauhan, Tania Luthra, Rambabu Gundla, Antonio Ferraro, Ulrike Holzgrabe, Subhabrata Sen*, A diversity oriented synthesis of natural product inspired molecular libraries. Organic and Biomolecular Chemistry, 2017, 15, 9108-9120.
  • Tania Luthra, Rahul Agarwal, Uma Adepally,* Mamidala, Estari, Subhabrata Sen* A novel library of a-arylketones as potential inhibitors of a-glucosidase: Their design, synthesis, in vitro and in vivo studies, Scientific Reports, 2017, 7, 13246 (DOI:10.1038/s41598-017-13798-y).
  • Santanu Hati, Ulrike Holzgrabe, Subhabrata Sen* Oxidative dehydrogenation of C-C and C-N bonds: A convenient approach to access diverse (dihydro) heteromatic compound, Beilstein J. Org. Chem. 2017, 13, 1670-1692.
  • Suresh Poudapally, Shankar Battu, Loka Reddy Velatooru, Murali Satyanarayana Bethu, Janapala Venkateswara Rao, Somesh Sharma, Subhabrata Sen, Narender Pottabathini, Vijaya Bhaskara Reddy Iska, Vidya Katangoor, Synthesis and Biological Evaluation of Novel Quinazoline-Sulfonamides as Anti-Cancer Agents, Bioorganic and Medicinal Chemistry Letters, 2017, http://dx.doi.org/10.1016/j.bmcl.2017.03.042
  • Santanu Hati and Subhabrata Sen* Cerium Chloride Catalyzed, 2-Iodoxybenzoic Acid Mediated Oxidative Dehydrogenation of Multiple Heterocycles at Room Temperature, European Journal of Organic Chemistry. 2017, 1277-1280
  • Pratip Kumar Dutta, Arpi Majumder, Sanjay Dutta, Basab Bijayi Dhar, Parthapratim Munshi and Subhabrata Sen* Solvent free, palladium catalyzed highly facile synthesis of diaryl disulfides from aryl thiols, Tetrahedron Letters, 2017, 58, 527-530
  • Naveen Kumar, Santanu Hati, Parthapratim Munshi, Seema Sehrawat, Subhabrata Sen and Shailja Singh* A novel spiroindoline targets cell cycle and migration via modulation of microtubule cytoskeleton, Molecular and Cellular Biochemistry, 2017, 429, 11-21
  • Dandugudumula Ramu, Swati Garg, R. Ayana, A. K. Keerthana, Vijeta Sharma, Subhabrata Sen, Soumya Pati and Shailja Singh* Novel -carboline-quinazolinone hybrids disrupt Leishmania donovani redox homeostasis and show promising antileishmanial activity, Biochemical Pharmacology, 2017, 129, 26-42
  • Chandramohan Bathula, Shreemoyee Ghosh, Santanu Hati, Sayantan Tripathi, Shailja Singh, Saikat Chakrabarti, Subhabrata Sen* Bioisosteric modification of known fucosidase inhibitors to discover a novel inhibitor of -L-fucosidase, RSC Advances, 2017, 7, 3563-3572.
  • Santanu Hati, Sayantan Tripathi, Pratip K. Dutta, Rahul Agarwal, Ramprasad Srinivasan, Ashutosh Singh, Shailja Singh, Subhabrata Sen* Spiro[pyrrolidine-3, 3´-oxindole] as potent anti-breast cancer compounds: Their design, synthesis, biological evaluation and cellular target identification, Scientific Report 2016, 6: 32213, 1-10.
  • Chandramohan Bathula, Sayantan Tripathi, Ramprasad Srinivasan, Kunal Kumar Jha, Arnab Ganguly, G. Chakraborty, Shailja Singh, Parthapratim Munshi, Subhabrata Sen* Synthesis of novel 5-arylidenethiazolidinones with apoptotic properties via a three component reaction using piperidine as a bifunctional reagent, Organic and Biomolecular Chemistry, 2016, 14, 8053-8063 (Accepted as inner cover page).
  • Santanu Hati, Pratip K. Dutta, Sanjay Dutta, Parthapratim Munshi and Subhabrata Sen* Accessing Benzimidazoles via a Ring Distortion Strategy: An Oxone Mediated Tandem Reaction of 2-Aminobenzylamines, Organic Letters, 2016, 18, 3090–3093.
  • Rajanikanth Mamidala, Papiya Mazumdar, Chandramohan Bathula, Rahul Agarwal, Kunal Kumar Jha, Hemanta Majumdar, Parthapratim Munshi, Subhabrata Sen* Identification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitors, Scientific Reports, 2016, 6:26603, 1-12
  • Rahul Agarwal, Ashutosh Singh and Subhabrata Sen*, Role of Molecular Docking in Computer Aided Drug Design and Development, Chapter-1, Applied Case Studies and Solutions in Molecular Docking-Based Drug, Design, ISBN 9781522503620, 2016, Publisher: IGI Global
  • Santanu Hati and Subhabrata Sen* Synthesis of Quinazolines and Dihydroquinazolines: o-Iodoxybenzoic Acid Mediated Tandem Reaction of o-Aminobenzylamine with Aldehydes, Synthesis. 2016, 48, 1389-1398
  • Santanu Hati and Subhabrata Sen* N-Bromo-succinimide promoted synthesis of b-carbolines and 3, 4-dihydro-b-carbolines from tetrahydro--carbolines, Tetlett. 2016, 57, 1040-1043
  • Chandramohan Bathula, R. Mamidala, C. Tulluri, Rahul Agarwal, K. K. Jha, U. Adepally, Ashutosh Singh, Parthapratim Munshi, M. Thirumalacharya and Subhabrata Sen* Substituted furopyridinediones as novel inhibitors of a-glucosidase, RSC Advances, 2015, 5, 90374-90385
  • Chandramohan Bathula, Poonam Dangi, Santanu Hati, Rahul Agarwal, Ashutosh Singh, Parthapratim Munshi, Shailja Singh and Subhabrata Sen* Diverse synthesis of natural product inspired fused and spiro-heterocyclic scaffolds via ring distortion and ring construction strategies, New Journal of Chemistry, 2015, 39, 9281-9292
  • Papiya Majumdar, Chandramohan Bathula, Suparna M. Basu, Subhendu K. Das, Rahul Agarwal, Santanu Hati, Ashutosh Singh, Subhabrata Sen,* Benu Brata Das*, Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity, European Journal of Medicinal Chemistry, 2015, 102, 540-551
  • Santanu Hati, Sanjay M. Madurkar, Chandramohan Bathula, Chiranjeevi Thulluri, Rahul Agarwal, Faiza Amber Siddiqui, Poonam Dangi, Uma Adepally, Ashutosh Singh, Shailja Singh*, Subhabrata Sen*, Design, synthesis and biological evaluation of small molecules as potent glucosidase inhibitors, A natural product based DOS library of hybrid systems, European Journal of Medicinal Chemistry, 2015, 100, 188-196
  • Ganesh Prabhu, Shalini Agarwal, Vijeta Sharma, Sanjay M. Madurkar, Parthapratim Munshi, Shailja Singh,* Subhabrata Sen*, A natural product based DOS library of hybrid systems, European Journal of Medicinal Chemistry, 2015, 95, 41-48
  • Chandramohan Bathula, Shailja Singh and Subhabrata Sen*, Diversity oriented synthesis for novel anti-malarials, Systems and Synthetic Biology, 2015, 9 (Supp 1), 49
  • Santanu Hati, Sudeepto Bhattacharya, Subhabrata Sen*, Innovative techniques to discover novel antimalarials, Systems and Synthetic Biology, 2015, 9 (Supp 1), 39
  • Vijeta Sharma, Shalini Agarwal, Sanjay M Madurkar, Gaurav Datta, Poonam Dangi, Ramu Dandugudumula, Subhabrata Sen,* and Shailja Singh*, Diversity-oriented synthesis and activity evaluation of substituted bicyclic lactams as anti-malarial against Plasmodium falciparum, Malaria Journal, 2014, 13, 1-11
  • Sudeepto Bhattacharya and Subhabrata Sen, Chapter-14, Applications of Metaheuristics in Process Engineering, ISBN 978-3-319-06507-6, 2014, Publisher :Springer
  • Subhabrata Sen*, Ganesh Prabhu, Chandramohan Bathula, Santanu Hati, Diversity Oriented Asymmetric Synthesis, Synthesis, 2014, 46, 2099-2121
  • Rajinikanth Mamidala, V. Surendra Babu Damerla, Rambabu Gundla, M. Thirumala Chary, Y. L. N. Murthy and Subhabrata Sen*,  Pyrrolidine and piperidine based chiral spiro and fused scaffolds via build/couple/pair approach RSC Adv., 2014, 4, 10619-10626
  • Nagamani Sukumar, Michael P.  Krein,  Ganesh  Prabhu,  Sudeepto  Bhattacharya  and Subhabrata Sen, Network Measures for Chemical Library Design, Drug Development Research, 2014, 75, 402–411
  • Subhabrata Sen*, Rajanikanth Mamidala, Rambabu Gundla and M. T. Charya, Diversity Oriented Synthesis of Macrocyclic Diaryl Ethers by Doetz Benzannulation, Asian Journal of Organic Chemistry, 2013, 2, 862–868
  • Ramu Surakanti, S. Sanivarapu, Chiranjeevi Thulluri, Pravin S. Iyer, Raghuram S. Tangirala, Rambabu Gundla, Dr. Uma Addepally, Y. L. N. Murthy, Lakshmi Velide and Subhabrata Sen*, Synthesis of Privileged Scaffolds by Using Diversity-Oriented Synthesis Chemistry An Asian Journal, 2013, 8, 1168–1176
  • Subhabrata Sen*, Siva R. Kamma, Rambabu Gundla, Uma Adepally, Santosh Kuncha, Sridhar Thirnathi and U. Viplava Prasad, A reagent based DOS strategy via Evans chiral auxiliary: highly stereoselective Michael reaction towards optically active quinolizidinones, piperidinones and pyrrolidinones, RSC Adv., 2013, 3, 2404-2411
  • Andrew M.K. Pennell, James B. Aggen, Subhabrata Sen, Wei Chen, Yuan Xu, Edward Sullivan, Lianfa Li, Kevin Greenman, Trevor Charvat, Derek Hansen, Daniel J. Dairaghi, J.J. Kim Wright, Penglie Zhang, 1-(4-Phenylpiperazin-1-yl)-2-(1H-pyrazol-1-yl)ethanones as novel CCR1 antagonists Bioorganic   &  Medicinal  Chemistry Letters, 2013, 23, 1228-1231.
  • Surendra Babu Damerla, Chiranjeevi Tulluri, Dr. Rambabu Gundla, Lava Naviri, Prof. Uma Adepally, Pravin S. Iyer, Prof. Y. L. N. Murthy, Nampally Prabhakar and Subhabrata Sen* Reagent-Based DOS: Developing a Diastereoselective Methodology to access Spirocyclic- and Fused Heterocyclic Ring Systems, Chemistry An Asian Journal, 2012, 7, 2351–2360.
  • Subhabrata Sen,* Siva R. Kamma, Venkata R. Potti, Y.L.N. Murthy, Avinash B. Chaudhary, Diversity-oriented synthesis of amino acids using chiral enolates, Tetrahedron Letters, 2011, 52, 5585-5588.
  • Subhabrata Sen,* Venkata R. Potti, Ramu Surakanti, Y. L. N. Murthy and Raghavaiah Pallepogu, Enantioselective synthesis of spirooxoindoles via chiral auxiliary (bicyclic lactam) controlled SNAr reactions, Org. Biomol. Chem., 2011, 9, 358-360
  • Dibenzofurans and their use as a medicament or as a fungicide. Subhabrata Sen*, Parag Kulkarni, Kailaskumar Borate and Nandini R Pai. Indian Patent Application, 2010, 46pp, IN2008KO01638
  • Subhabrata Sen,* Kailaskumar Borate, Parag Kulkarni, Nandini R. Pai, Reaction of substituted alkynols with alkoxycarbene complexes of chromium: a facile synthesis of substituted , -unsaturated-c-butyrolactones, Tetrahedron Letters, 2009, 50, 5001-5004
  • Subhabrata Sen,* Parag Kulkarni, Kailaskumar Borate, Nandini R. Pai, Synthesis of novel oxygen heterocycles: 1,10-dioxa-cyclopenta[a]fluorine and benzo[b]naphtho[2, 1-d]furans via Dötz intramolecular benzannulation, Tetrahedron Letters, 2009, 50, 4128-4131
  • Samir Ghosh, A. Sanjeev Kumar, G. N. Mehta, R. Soundararajan* and Subhabrata Sen, Formal synthesis of piperazinomycin, a novel antifungal antibiotic ARKIVOC, 2009, vii, 72-78
  • Substituted piperazines. Andrew M. K. Pennell, James B. Aggen, J. J. Kim. Wright, Subhabrata Sen, Brian E. McMaster, Daniel Dairaghi, US 7449576, 2008
  • Bicyclic and bridged nitrogen heterocycles. Wei Chen, Penglie Zhang, James B. Aggen, Daniel Dairaghi, Andrew M. K. Pennell, Subhabrata Sen, J. J. Kim Wright. US 7435831, 2008
  • Substituted Piperazines. Andrew M. K. Pennell, James B. Aggen, J. J. Kim Wright, Subhabrata Sen, Brian E. McMaster, Daniel J. Dairaghi. WO/2005/056015, 2005
  • Anuradha Gupta, Subhabrata Sen, Michael Harmata, and Shon R. Pulley, Synthesis of (S, S)-Isodityrosine by Dötz Benzannulation, 2005, Journal of Organic Chemistry 18, 7422-742
  • 1-aryl-4-substituted piperazines derivatives for use as CCR1 antagoisys for the treatment of inflammation and immune disorders. Andrew M. K. Pennell, James B. Aggen, J. J. Kim Wright, Subhabrata Sen, Brian E. McMaster, Daniel J. Dairaghi. WO/2003/105853, 2003.
  • Shon R. Pulley, Subhabrata Sen, Andrei Vorogushin, and Erika Swanson, Diaryl Ethers Using Fischer Chromium Carbene Mediated Benzannulation, 1999, Organic  Letters 1, 1721-1723

Contact Details

TOP