Our research group mainly focuses on the genetics of aging; particularly in understanding the dietary restriction (DR) mediated longevity. We use C. elegans as our main model to study the biology of aging. We use combination of genetics, behavioural, and molecular approaches to study effects of DR on lifespan and, the cost (fitness) associated with it. We are actively working on elucidating the roles of nuclear hormone receptors (NHR) in mediating the diverse signals from various longevity pathways such as DR signalling, insulin signalling (ILS), germline signalling, etc., in C. elegans. Also, we aim to use C. elegans as model aspect to study age related neurodegenerative diseases including Alzheimer's, Parkinson’s, and Huntington’s diseases.
Awards & Fellowships
2018-2021: DST SERB Early Career Research award (INR 44,53,000)
2016-2021: DST INSPIRE Faculty award (INR 50,00,000 fellowship, 35,00,000 grant Amount, total >85,00,000)
2014: Awarded PhD with highest possible distinction from ENS Lyon, France
2014: Final year thesis award from Fondation pour la Recherche Médicale (FRM), Lyon, France (€36000)
2010-2013: Ph.D. Research Scholarship Cluster de recherche region Rhone-Alpes,France
2007-2009: Junior Research Fellowship, JNCASR, Bangalore, India
2005: Qualified Graduate Aptitude Test for Engineers (GATE) with AIR 335
2017: TIFR centre for Interdisciplinary Sciences (TCIS), Hyderabad
2017: B.M.S College of Engineering, Bangalore
2017: UKIERI-UGC Workshop on Animal models in Cancer biology, UoH Hyderabad
2016: Indian Institute of Science Education and Research (IISER), Pune
2013: Gordon Research Conference on Biology of Aging, Tuscany, Italy
2012: Conference on Nuclear Hormone Receptors, Lyon, France
The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenhorhabditis elegans - Das, R., Melo, J, A., Thondamal M., Kim. J, H., Swartz, E, W., Douglas, p, M., Samuelson, A, V. PLoS Gen. 13(10) 2017.
HIF-1-dependent regulation of lifespan in Caenorhabditis elegans by the acyl-CoA-binding protein MAA-1-M., Dhaoui, M., Thondamal. M., Harvald,E, B., Færgeman, N., Aguilaniu, H., and Fabrizio, P. Aging 4(7) 2017.
Steroid hormone signalling links reproduction to lifespan in dietary restricted Caenorhabditis elegans - Thondamal, M., Witting, M., Schmitt-Kopplin, P., and Aguilaniu, H. Nat. Comm. 5:48792014.
Fast separation and quantification of steroid hormones Δ4- and Δ7-dafachronic acid in Caenorhabditis elegans - Witting, M., Rudolf, H, C., Thondamal, M., Aguilaniu, H., and Schmitt-Kopplin, P. J Chromatogr B Analyt Technol Biomed Life Sci. 978-979 (118-121) 2014.
Temperature can entrain egg laying rhythm of Drosophila but may not be a stronger zeitgeber than light - Kannan NN, Reveendran R, Hari Dass S, Manjunatha T, Sharma VK. J InsectPhysiol. 58(2) 245-255 2012.
Egg-laying rhythm in Drosophila melanogaster - Manjunatha T., Shantala Hari Dass and Vijay Kumar Sharma J Genet. 87(5) 495-04 2008.