Assistant Professor

Dr Balaji Babu

Department of Chemistry

Interests

  1. Photodynamic therapy (PDT) and Photodynamic antimicrobial chemotherapy (PACT)
  2. Porphyrinoids – Porphyrin, N-Confused porphyrin, Corrole, Chlorin
  3. Ferrocene conjugates

Faculty Details

Education

2007

Presidency College,
Chennai
BSc

2009

College of Engineering
(Guindy Campus),
Anna University – Chennai
MSc

2015

Indian Institute of Science (IISC),
Bengaluru
PhD

Experience

  • Oct 2020 to Jun 2021 – Postdoctoral fellow – Rhodes University, South Africa.
  • Sep 2019 to Sep 2020 – Postdoctoral fellow – Rhodes University, South Africa.
  • May 2017 to May 2019 – Postdoctoral fellow – Rhodes University, South Africa.
  • Sep 2016 to May 2017 – Assistant Professor – PSG College of Technology, Coimbatore.
  • Jul 2015 to Sep 2016 – Assistant Professor (contract) – Gandhigram Rural Institute, Dindigul.
  • Jul 2014 to Jul 2015 – Research Associate – Indian Institute of Science (IISC), Bengaluru.

Research Interest

  • Design and synthesis of novel porphyrin and other macrocyclic photosensitizers for its potential application in near-IR activated photodynamic therapy (PDT).
  • Ferrocene-baseded molecules for biomedical and chemical sensing applications.

Publications

  • 1. A Sn(IV) porphyrin with mitochondria targeting properties for enhanced photodynamic activity against MCF-7 cells - B. Babu, J. Mack, T. Nyokong - New Journal of Chemistry, 46, 5288–5295 (2022).
  • 2. Photodynamic antitumor and photodynamic antimicrobial activities of free base tetra(4-methylthiolphenyl)chlorin and its Sn(IV) complex – S. Dingiswayo, K. Burgess, B. Babu, J. Mack, T. Nyokong - ChemPlusChem, 87, e202200115 (2022).
  • 3. Novel cationic-chalcone phthalocyanines for photodynamic therapy eradication of S. aureus and E. coli bacterial biofilms and MCF-7 breast cancer – Y. I. Openda, B. Babu, T. Nyokong - Photodiagnosis and Photodynamic Therapy, 38, 102863 (2022).
  • 4. Sn(IV) porphyrin-biotin decorated nitrogen doped graphene quantum dots nanohybrids for photodynamic therapy - N. B. Magaela, R. Matshitse, B. Babu, M. Managa, E. Prinsloo, T. Nyokong - Polyhedron, 213, 115624 (2022).
  • 5. The photodynamic activities of the gold nanoparticle conjugates of phosphorus(V) and gallium(III) A3 meso-triarylcorroles – R. C. Soy, B. Babu, J. Mack, T. Nyokong – Dyes and Pigments, 194, 109631 (2021).
  • 6. Positively charged styryl pyridine substituted Zn (II) Phthalocyanines for Photodynamic Therapy and Photoantimicrobial Chemotherapy: Effect of the number of charges – A. Magadla, B. Babu, J. Mack, T. Nyokong - Dalton Transactions, 50, 9129-9136 (2021).
  • 7. The photophysicochemical properties and photodynamic therapy activity of Schiff base substituted phthalocyanines doped into silica nanoparticles and conjugated to folic acid -A. Magadla, B. Babu, P. Sen, T. Nyokong – Polyhedron, 203, 1152273 (2021).
  • 8. A heavy-atom-free π-extended N-confused porphyrin as a photosensitizer for photodynamic therapy – B. Babu, J. Mack, T. Nyokong - New Journal of Chemistry, 45, 5654-5658 (2021).
  • 9. Photodynamic activity and photoantimicrobial chemotherapy studies of ferrocene-substituted 2-thiobarbituric acid – B. Babu, T. Ochappan, T. A. Ali, J. Mack, T. Nyokong, M. G. Sethuraman - Bioorganic & Medicinal Chemistry Letters, 40, 127922 (2021).
  • 10. Naked Eye and Colorimetric Detection of Cyanide with a 1,3-Diethyl-2-thiobarbituric Acid Substituted Ferrocene Chemosensor - ChemistrySelect, 6, 1448-1452 (2021).
  • 11. Photodynamic activity of Sn(IV) tetrathien-2-ylchlorin against MCF-7 breast cancer cells - B. Babu, J. Mack, T. Nyokong - Dalton Transactions, 50, 2177-2182 (2021).
  • 12. Photocytotoxicity of heavy-atom-free thiobarbituric acid functionalized pyrene derivatives against MCF-7 cancer cells -B. Babu, T. A. Ali, T. Ochappan, J. Mack, T. Nyokong, M. G. Sethuraman - Photodiagnosis and Photodynamic Therapy, 33, 102102 (2021).
  • 13. Photodynamic activity of 2,6-dibrominated dimethylaminophenylbuta-1,3-dienylBODIPY dyes – G. Kubheka, B. Babu, E. Prinsloo, N. Kobayashi, J. Mack T. Nyokong – Journal of Porphyrins and Phthalocyanines, 25, 47-55 (2021).
  • 14. Thien-2-yl substituted chlorins as photosensitizers for photodynamic therapy and photodynamic antimicrobial chemotherapy – B. Babu, A. Sindelo, J. Mack, T.Nyokong - Dyes and Pigments, 185, 108886 (2021).
  • 15. Sn(IV) N-confused porphyrins as photosensitizer dyes for photodynamic therapy in the near IR region - B. Babu, J. Mack, T. Nyokong - Dalton Transactions, 49, 15180-15183 (2020).
  • 16. An octabrominated Sn(IV) tetraisopropylporphyrin as a photosensitizer dye for singlet oxygen biomedical applications - B. Babu, J. Mack, T. Nyokong - Dalton Transactions, 49, 9568-9573 (2020).
  • 17. Non-aggregated lipophilic water-soluble tin porphyrins as photosensitizers for photodynamic therapy and photodynamic antimicrobial chemotherapy - B. Babu, , R. C. Soy, J. Mack, T. Nyokong - New Journal of Chemistry, 44, 11006-11012 (2020).
  • 18. Photodynamic activity of 2, 6-diiodo-3, 5-dithienylvinyleneBODIPYs and their folate-functionalized chitosan-coated Pluronic® F-127 micelles on MCF-7 breast cancer cells – N. Molupe, B. Babu, D. O. Oluwole, E. Prinsloo, L. Gai, Z. Shen, J. Mack, T. Nyokong - Journal of Porphyrins and Phthalocyanines, 24, 973-984 (2020).
  • 19. The photophysicochemical properties and photodynamic therapy activity of In and Zn phthalocyanines when incorporated into individual or mixed Pluronic® micelles - B. M. Motloung, B.Babu, E.Prinsloo, T. Nyokong – Polyhedron, 188, 114683 (2020).
  • 20. A comparative study of the photophysicochemical and photodynamic activity properties of meso-4- methylthiophenyl functionalized Sn(IV) tetraarylporphyrins and triarylcorroles – S. Dingiswayo, B. Babu, E. Prinsloo, J. Mack, T. Nyokong - Journal of Porphyrins and Phthalocyanines, 24, 1138–1145 (2020).
  • 21. Susceptibility of Staphylococcus aureus to porphyrin-silver nanoparticle mediated photodynamic antimicrobial chemotherapy – S. M Shabangu, B. Babu, R. C. Soy, J. Oyim, E. Amuhaya, T. Nyokong - Journal of Luminescence, 222, 117158 (2020).
  • 22. Photodynamic antimicrobial chemotherapy of asymmetric porphyrin-silver conjugates towards photoinactivation of Staphylococcus aureus – S. M. Shabangu, B. Babu, R. C. Soy, M. Managa, K. E. Sekhosana, T. Nyokong – Journal of Coordination Chemistry, 73 (4), 593-608 (2020).
  • 23. Photodynamic activity of Sn(IV) meso-tetraacenaphthylporphyrin and its methyl-cyclodextrin inclusion complexes on MCF-7 breast cancer cells – N. Molupe, B. Babu, E. Prinsloo, A. Y. A. Kaassis , K. Edkins, J. Mack, T. Nyokong - Journal of Porphyrins and Phthalocyanines, 23, 1486-1494 (2019).
  • 24. Photophysicochemical properties and photodynamic therapy activity of chloroindium(III) tetraarylporphyrins and their gold nanoparticle conjugates - R C. Soy, B. Babu, D. O. Oluwole, N. Nwaji, J. Oyim, E. Amuhaya, E. Prinsloo, J. Mack, T. Nyokong - Journal of Porphyrins and Phthalocyanines, 23, 34-45 (2019).
  • 25. Synthesis, characterization and photodynamic activity of Sn (IV) triarylcorroles with red-shifted Q bands – B. Babu, E. Prinsloo, J. Mack, T. Nyokong - New Journal of Chemistry, 43, 18805-18812 (2019).
  • 26. Preparation of NIR absorbing axial substituted tin(IV) porphyrins and their photocytotoxic properties – B. Babu, E. Amuhaya, D. O. Oluwole, E. Prinsloo, J. Mack, T. Nyokong – MedChemComm, 10, 41-48 (2019).
  • 27. The investigation of in vitro dark cytotoxicity and photodynamic therapy effect of a 2,6-dibromo-3,5-distyryl BODIPY dye encapsulated in Pluronic® F-127 micelles – N. Molupe, B. Babu, D. O. Oluwole, E. Prinsloo, J. Mack, T. Nyokong - Journal of Coordination Chemistry, 71, 3444-3457 (2018).
  • 28. Mitochondria Targeting Ferrocene Conjugates of N-Alkyl Pyridinium Salts – B. Babu, B. Balakrishnan, S.Perumalla, A. A. Karande, A. R. Chakravarty - European Journal of Inorganic Chemistry, 1398-1407 (2015).
  • 29. Photocytotoxic Ferrocenyl Terpyridine Oxovanadium(IV) Complexes of Acetylacetonate Derivatives - B. Babu, B. Balakrishnan, S.Perumalla, A. A. Karande, A. R. Chakravarty – European Journal of Medicinal Chemistry, 92, 332-341 (2015).
  • 30. Photoactivated cytotoxicity of ferrocenyl-terpyridine oxovanadium(IV) complexes of curcuminoids - B. Babu, B. Balakrishnan, S.Perumalla, A. A. Karande, A. R. Chakravarty – European Journal of Medicinal Chemistry, 85, 458-467 (2014).
  • 31. Ferrocenyl-L-amino acid copper(II) complexes showing remarkable photo-induced anticancer activity in visible light – T. K. Goswami, S. Gadadhar, B. Babu, B. Gole, A. A. Karande, A. R. Chakravarty - Dalton Transactions, 43, 11988-11999 (2014).
  • 32. Photoactivated DNA cleavage and anticancer activity of oxovanadium(IV) complexes of curcumin – B. Babu, K. Somyajit, B. Banik, G. Nagaraju, A. R. Chakravarty - Inorganica Chimica Acta, 400, 142-150 (2013).
  • 33. Ferrocene Conjugated Oxidovanadium(IV) Complexes as Potent Near-IR Light Photocytotoxic Agents – B. Babu, B. Banik, P. K. Sasmal, B. Maity, R. Majumdar, R. R. Dighe, A. R. Chakravarty - European Journal of Inorganic Chemistry, 126-135 (2012).

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