Area of Research: Dietary restriction and genetics of aging in C. elegans
FUNDING AGENCY: DST INSPIRE and SERB
POSITION: Junior Research Fellow (JRF)
No. OF POSITIONS: 2
Eligibility: Candidates with a keen interest in basic science research and prior hands-on experience with molecular Biology, genetics, biochemistry or microbiology techniques are preferred.
- Post Graduate Degree in life Science
- Graduate Degree in Professional Course (B.Tech. Biotechnology or similar)
- Post Graduate Degree in Professional Course (M.Tech. Biotechnology or similar)) NETs accepted: CSIR-NET including LS; GATE, JAM, GPAT, BET, JEST, JGEEBILS, ICMR-JRF and ICAR- AICE
EMOLUMENTS AND DURATION
Rs. 25000+HRA per month (for CSIR-NET including LS; GATE, JAM, GPAT, BET, JEST, JGEEBILS, ICMR-JRF and ICAR- AICE)
Rs. 16000+HRA per month (for others)
Duration: 3 years.
Selected student can be registered for full time Ph.D. program at SRM University AP, Amaravati.
DEADLINE: 20 March, 2019
The availability of complete genome sequence along with powerful molecular and genetic tools has made the nematode Caenorhabditis elegans as one of the widely studied model organism in the field of developmental biology, neuroscience, and adult lifespan. Several studies indicate that sensors and regulators of cell metabolism modulate organismal aging. Signaling mechanisms, such as insulin/IGF (ILS), mTOR, AMPK, sirtuins, and the dietary restriction (DR) pathways have been largely implicated in organismal lifespan. DR is one of the robust non-genetic intervention shown to positively regulate healthspan and lifespan in many species. However, lifespan increasing effect of DR is often accompanied by impaired reproduction. With the advantage of short lifespan and availability of powerful genetic tools in C. elegans, we would like to focus on addressing following two main questions:
Does DR protects germline stem cells (GSC) and hence contribute to fitness later when conditions are favorable?
Do nuclear hormone receptors (NHRs) integrate signals from known pathways that mediate C. elegans longevity?
Qualified and interested candidates may send their curriculum vitae by e-mail to email@example.com on or before deadline. Please mention in the subject line of the mail the following code: - Aging – C. elegans. Selected candidates will be called for a personal interview to SRM University AP, Amaravati, Neerukonda.