Dr. Thondamal obtained his PhD with ‘tres honorbale’ (highest distinction) from Ecole Normale Superieure (ENS) de Lyon, France in 2014. He did his postdoctoral research at University of Rochester Medical Center, Rochester, NY USA. He joined Dr. Reddy’s Institute of Life Sciences (DRILS), Hyderabad as DST INSPIRE Faculty in 2016. He is a SERB-ECR Awardee (2018_. Currently, Dr. Thondamal is an Assistant Professor at Department of Biology, SRM University AP. Dr. Thondamal is also a visiting scientist at Institut Pasteur, Paris.
Areas of Research Interest
a) Genetics of aging
b) Dietary Restriction and healthspan
c) Mitochondrial morphology and aging
Dr. Thondamal’s research group at SRM University AP, Amaravati, mainly focuses on the genetics of aging; particularly in understanding the dietary restriction (DR) mediated longevity. By adopting C. elegans as main model, his group studies the biology by utilizing various tools in genetics, behavioral, and molecular approaches. His group studies effects of DR on lifespan and, the cost (fitness) associated with it. Recently, Dr. Thondamal has initiated research projects on studying age related neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases by using C. elegans as model aspect. Dr. Thondamal is also working in collaboration with Pasteur Institute, Paris, where he is currently visiting to establish a C. elegans facility to conduct research on role of mitochondrial morphology in regulating organismal healthspan and aging.
1. Das, R., Melo, J, A., Thondamal, M., Kim. J, H., Swartz, E, W., Douglas, p, M., Samuelson, A, V. “The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenhorhabditis elegans” PLoS Gen. 2017
2. Thondamal, M., Witting, M., Schmitt-Kopplin, P., and Aguilaniu, H. “Steroid hormone signalling links reproduction to lifespan in dietary restricted Caenorhabditis elegans” Nat. Comm. 2014.
3. Shamalnasab,M., Dhaoui, M., Thondamal,M., Harvald,E, B., Færgeman, N., Aguilaniu, H., and Fabrizio, P. "HIF-1-dependent regulation of lifespan in Caenorhabditis elegans by the acyl-CoA- binding protein MAA-1" Aging 2017
Google scholar link - https://scholar.google.com/citations?user=lwP_-F0AAAAJ&hl=en&oi=ao
Faculty Profile - https://srmap.edu.in/faculty/dr-manjunatha-thondamal/