Professor

Dr. Subhabrata Sen

Department of Chemistry

Interests

  1. Synthetic Organic Chemistry
  2. Molecular Library Design
  3. Medicinal Chemistry

Education

1994

Narendrapur Ramakrishna Mission Residential College, Calcutta University
India
Bachelors

1996

Kalyani University
India
Masters

2001

University of Missouri-Columbia
India
Ph.D.

Experience

  • 08/2018 – Present, Professor | Department of Chemistry, SRM University, AP
  • 07/2016 – 07/2018, Associate Professor and Head | Department of Chemistry, Shiv Nadar University
  • 02/2013 – 06/2016, Associate Professor | Shiv Nadar University
  • 03/2010 – 12/2012, Associate Director | GVK Bioscience Hyderabad, TE, India
  • 02/2009 – 02/2010, Principal Scientist | Jubilant Chemsys, Noida, UP, India
  • 02/2008 – 01/2009, Senior Manager | Pfizer VMPS, Mumbai, India
  • 03/2006 – 01/2008, Senior Scientist | BASF-India, Mumbai India
  • 04/2004 – 02/2006, Scientific manager | Syngene International Private Limited, Bangalore, India
  • 09/2002 – 03/2006, Scientist-1 | Chemocentryx Inc., Mountain View, California
  • 06/2001 – 08/2002, Research Scientist | Prof. Albert I Meyers, Department of Chemistry, Colorado State Fort Collins, Ft. Collins, CO, USA

Research Interest

  • Development of organo- and metal catalysed strategies to access bioactive heterocycles
  • Development of diverse asymmetric strategies to synthesize 3-dimentional molecules
  • Target based discovery research in:
    • Malaria (first in class targets)
    • Type II diabetes (a-glucosidase)
    • Cancer (indoleamine-2, 3-dioxygenase and tubulin)

Research Interests ( Mentoring detail)

  • Completed PhD: Advisor: 3; Co-Advisor: 4
  • Ongoing PhD: Advisor: 3; Co-Advisor: 1

Awards & Fellowships

  • 2003: “Make it Happen” Award: Chemocentryx Inc., Mt. View, California, USA
  • Department of Science and Technology Travel Grant-2015
  • 2016: Seibold-Collegium Fellowship, Seibold Collegium Institute of Advances Studies, Julius-Maxmillians-Universität Würzburg, Würzburg, Germany

Publications

  • An iodine catalyzed metal free oxidative ring opening of 1-aryltetrahydro-b-carbolines: Facile synthesis of C2 aroyl and aryl methanimino indole derivatives. Jyoti Chauhan, Tania Luthra and Subhabrata Sen*, Just Accepted, European Journal of Organic Chemistry, 2018, 1002/ejoc.201800879
  • Aerobic oxidative amidation of alkynes using titanium oxide encapsulated cuprous iodide nanoparticles (CuI@TiO2). Pratip Dutta, Basabbijayi Dhar and Subhabrata Sen*, New Journal of Chemistry, 2018, 42, 12062
  • Synthesis of tetrahydro-1H-indolo[2, 3-b]pyrrolo[3, 2-c]quinolones via intramolecular oxidative ring rearrangement of tetrahydro-b-carbolines and their biological evaluation. Chandramohan Bathula, Catarina Roma-Rodrigues, Jyoti Chauhan, Alexandra R. Fernandes* and Subhabrata Sen,* Just accepted New Journal of Chemistry, 2018, DOI: 10.1039/C7NJ04616B.
  • Solid Supported nano structured Cu-Catalyst for solvent/ligand free C2 Amination of Azoles. Pratip K. Dutta, Subhabrata Sen,* Debasree Saha* and Basabbijayi Dhar, J. Org. Chem. 2017, Just Accepted, DOI: 10.1002/ejoc.201701669.
  • A diversity oriented synthesis of natural product inspired molecular libraries. Jyoti Chauhan, Tania Luthra, Rambabu Gundla, Antonio Ferraro, Ulrike Holzgrabe, Subhabrata Sen*, Organic and Biomolecular Chemistry, 2017, 15, 9108-9120.
  • A novel library of a-arylketones as potential inhibitors of a-glucosidase: Their design, synthesis, in vitro and in vivo Tania Luthra, Rahul Agarwal, Uma Adepally,* Mamidala, Estari, Subhabrata Sen* Nature Scientific Reports, 2017, 7, 13246 (DOI:10.1038/s41598-017-13798-y).
  • Oxidative dehydrogenation of C-C and C-N bonds: A convenient approach to access diverse (dihydro) heteromatic compound. Santanu Hati, Ulrike Holzgrabe, Subhabrata Sen* Beilstein J. Org. Chem. 2017, 13, 1670-1692.
  • Synthesis and Biological Evaluation of Novel Quinazoline-Sulfonamides as Anti-Cancer Agents. Suresh Poudapally, Shankar Battu, Loka Reddy Velatooru, Murali Satyanarayana Bethu, Janapala Venkateswara Rao, Somesh Sharma, Subhabrata Sen, Narender Pottabathini, Vijaya Bhaskara Reddy Iska, Vidya Katangoor, Bioorganic and Medicinal Chemistry Letters, 2017, http://dx.doi.org/10.1016/j.bmcl.2017.03.042
  • Cerium Chloride Catalyzed, 2-Iodoxybenzoic Acid Mediated Oxidative Dehydrogenation of Multiple Heterocycles at Room Temperature. Santanu Hati and Subhabrata Sen* European Journal of Organic Chemistry. 2017, 1277-1280
  • Solvent free, palladium catalyzed highly facile synthesis of diaryl disulfides from aryl thiols. Pratip Kumar Dutta, Arpi Majumder, Sanjay Dutta, Basab Bijayi Dhar, Parthapratim Munshi and Subhabrata Sen* Tetlett, 2017, 58, 527-530
  • A novel spiroindoline targets cell cycle and migration via modulation of microtubule cytoskeleton. Naveen Kumar, Santanu Hati, Parthapratim Munshi, Seema Sehrawat, Subhabrata Sen and Shailja Singh* Molecular and Cellular Biochemistry, 2017, 429, 11-21
  • Novel b-carboline-quinazolinone hybrids disrupt Leishmania donovani redox homeostasis and show promising antileishmanial activity. Dandugudumula Ramu, Swati Garg, R. Ayana, A. K. Keerthana, Vijeta Sharma, Subhabrata Sen, Soumya Pati and Shailja Singh* Biochemical Pharmacology, 2017, 129, 26-42
  • Bioisosteric modification of known fucosidase inhibitors to discover a novel inhibitor of a-L-fucosidase. Chandramohan Bathula, Shreemoyee Ghosh, Santanu Hati, Sayantan Tripathi, Shailja Singh, Saikat Chakrabarti, Subhabrata Sen* RSC Advances, 2017, 7, 3563-3572.
  • Spiro[pyrrolidine-3, 3´-oxindole] as potent anti-breast cancer compounds: Their design, synthesis, biological evaluation and cellular target identification. Santanu Hati, Sayantan Tripathi, Pratip K. Dutta, Rahul Agarwal, Ramprasad Srinivasan, Ashutosh Singh, Shailja Singh, Subhabrata Sen* Nature Scientific Report 2016, 6: 32213, 1-10.
  • Synthesis of novel 5-arylidenethiazolidinones with apoptotic properties via a three component reaction using piperidine as a bifunctional reagent. Chandramohan Bathula, Sayantan Tripathi, Ramprasad Srinivasan, Kunal Kumar Jha, Arnab Ganguly, G. Chakraborty, Shailja Singh, Parthapratim Munshi, Subhabrata Sen* Organic and Biomolecular Chemistry, 2016, 14, 8053-8063 (Accepted as inner cover page).
  • Accessing Benzimidazoles via a Ring Distortion Strategy: An Oxone Mediated Tandem Reaction of 2- Santanu Hati, Pratip K. Dutta, Sanjay Dutta, Parthapratim Munshi and Subhabrata Sen* Org. Lett.,2016, 18, 3090–3093.
  • Identification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 Rajanikanth Mamidala, Papiya Mazumdar, Chandramohan Bathula, Rahul Agarwal, Kunal Kumar Jha, Hemanta Majumdar, Parthapratim Munshi, Subhabrata Sen* Nature Scientific Reports, 2016, 6:26603, 1-12
  • Role of Molecular Docking in Computer Aided Drug Design and Development. Rahul Agarwal, Ashutosh Singh and Subhabrata Sen, Chapter-1, Applied Case Studies and Solutions in Molecular Docking-Based Drug, Design, ISBN 9781522503620, 2016, Publisher: IGI Global
  • Synthesis of Quinazolines and Dihydroquinazolines: o-Iodoxybenzoic Acid Mediated Tandem Reaction of o-Aminobenzylamine with Aldehydes. Santanu Hati and Subhabrata Sen* Synthesis. 2016, 48, 1389-1398
  • N-Bromo-succinimide promoted synthesis of b-carbolines and 3, 4-dihydro-b-carbolines from tetrahydro-b-carbolines. Santanu Hati and Subhabrata Sen* Tetlett. 2016, 57, 1040-1043
  • Substituted furopyridinediones as novel inhibitors of a-glucosidase. Chandramohan Bathula, R. Mamidala, C. Tulluri, Rahul Agarwal, K. K. Jha, U. Adepally, Ashutosh Singh, Parthapratim Munshi, M. Thirumalacharya and Subhabrata Sen* RSC Advances, 2015, 5, 90374-90385
  • Diverse synthesis of natural product inspired fused and spiro-heterocyclic scaffolds via ring distortion and ring construction strategies. Chandramohan Bathula, Poonam Dangi, Santanu Hati, Rahul Agarwal, Ashutosh Singh, Parthapratim Munshi, Shailja Singh and Subhabrata Sen* New Journal of Chemistry, 2015, 39, 9281-9292
  • Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity. Papiya Majumdar, Chandramohan Bathula, Suparna M. Basu, Subhendu K. Das, Rahul Agarwal, Santanu Hati, Ashutosh Singh, Subhabrata Sen,* Benu Brata Das*, European Journal of Medicinal Chemistry, 2015, 102, 540-551
  • Design, synthesis and biological evaluation of small molecules as potent glucosidase inhibitors, A natural product based DOS library of hybrid systems. Santanu Hati, Sanjay M. Madurkar, Chandramohan Bathula, Chiranjeevi Thulluri, Rahul Agarwal, Faiza Amber Siddiqui, Poonam Dangi, Uma Adepally, Ashutosh Singh, Shailja Singh*, Subhabrata Sen*, European Journal of Medicinal Chemistry, 2015, 100, 188-196
  • A natural product based DOS library of hybrid systems. Ganesh Prabhu, Shalini Agarwal, Vijeta Sharma, Sanjay M. Madurkar, Parthapratim Munshi, Shailja Singh,* Subhabrata Sen*, European Journal of Medicinal Chemistry, 2015, 95, 41-48
  • Diversity oriented synthesis for novel anti-malarials. Chandramohan Bathula, Shailja Singh and Subhabrata Sen*, Systems and Synthetic Biology, 2015, 9 (Supp 1), 49
  • Innovative techniques to discover novel antimalarials. Santanu Hati, Sudeepto Bhattacharya, Subhabrata Sen*, Systems and Synthetic Biology, 2015, 9 (Supp 1), 39
  • Diversity-oriented synthesis and activity evaluation of substituted bicyclic lactams as anti-malarial against Plasmodium falciparum. Vijeta Sharma, Shalini Agarwal, Sanjay M Madurkar, Gaurav Datta, Poonam Dangi, Ramu Dandugudumula, Subhabrata Sen,* and Shailja Singh*, Malaria Journal, 2014, 13, 1-11
  • Applications of Metaheuristics in Process Engineering. Sudeepto Bhattacharya and Subhabrata Sen, Chapter-14, ISBN 978-3-319-06507-6, 2014, Publisher :Springer
  • Diversity Oriented Asymmetric Synthesis, Synthesis. Subhabrata Sen*, Ganesh Prabhu, Chandramohan Bathula, Santanu Hati, 2014, 46, 2099-2121
  • Pyrrolidine and piperidine based chiral spiro and fused scaffolds via build/couple/pair approach. Rajinikanth Mamidala, V. Surendra Babu Damerla, Rambabu Gundla, M. Thirumala Chary, Y. L. N. Murthy and Subhabrata Sen*, RSC Adv., 2014, 4, 10619-10626
  • Network Measures for Chemical Library Design, Drug Development Research. Nagamani Sukumar, Michael P. Krein,  Ganesh  Prabhu,  Sudeepto  Bhattacharya  and Subhabrata Sen, 2014, 75, 402–411
  • Diversity Oriented Synthesis of Macrocyclic Diaryl Ethers by Doetz Benzannulation. Subhabrata Sen*, Rajanikanth Mamidala, Rambabu Gundla and M. T. Charya, Asian Journal of Organic Chemistry, 2013, 2, 862–868
  • Synthesis of Privileged Scaffolds by Using Diversity-Oriented Synthesis. Ramu Surakanti, S. Sanivarapu, Chiranjeevi Thulluri, Pravin S. Iyer, Raghuram S. Tangirala, Rambabu Gundla, Dr. Uma Addepally, Y. L. N. Murthy, Lakshmi Velide and Subhabrata Sen*, Chemistry An Asian Journal, 2013, 8, 1168–1176
  • A reagent based DOS strategy via Evans chiral auxiliary: highly stereoselective Michael reaction towards optically active quinolizidinones, piperidinones and pyrrolidinones. Subhabrata Sen*, Siva R. Kamma, Rambabu Gundla, Uma Adepally, Santosh Kuncha, Sridhar Thirnathi and U. Viplava Prasad, , RSC Adv., 2013, 3, 2404-2411
  • 1-(4-Phenylpiperazin-1-yl)-2-(1H-pyrazol-1-yl)ethanones as novel CCR1 antagonists. Andrew M.K. Pennell, James B. Aggen, Subhabrata Sen, Wei Chen, Yuan Xu, Edward Sullivan, Lianfa Li, Kevin Greenman, Trevor Charvat, Derek Hansen, Daniel J. Dairaghi, J.J. Kim Wright, Penglie Zhang, Bioorganic &  Medicinal  Chemistry Letters, 2013, 23, 1228-1231.
  • Reagent-Based DOS: Developing a Diastereoselective Methodology to access Spirocyclic- and Fused Heterocyclic Ring Systems. V. Surendra Babu Damerla, Chiranjeevi Tulluri, Dr. Rambabu Gundla, Lava Naviri, Prof. Uma Adepally, Pravin S. Iyer, Prof. Y. L. N. Murthy, Nampally Prabhakar and Subhabrata Sen*, Chemistry An Asian Journal, 2012, 7, 2351–2360.
  • Diversity-oriented synthesis of amino acids using chiral enolates. Subhabrata Sen,* Siva R. Kamma, Venkata R. Potti, Y.L.N. Murthy, Avinash B. Chaudhary, Tetrahedron Letters, 2011, 52, 5585-5588.
  • Enantioselective synthesis of spirooxoindoles via chiral auxiliary (bicyclic lactam) controlled SNAr reactions. Subhabrata Sen,* Venkata R. Potti, Ramu Surakanti, Y. L. N. Murthy and Raghavaiah Pallepogu, , Biomol. Chem., 2011, 9, 358-360
  • Reaction of substituted alkynols with alkoxycarbene complexes of chromium: a facile synthesis of substituted a, b-unsaturated-c-butyrolactones. Subhabrata Sen,* Kailaskumar Borate, Parag Kulkarni, Nandini R. Pai, Tetrahedron Letters, 2009, 50, 5001-5004
  • Synthesis of novel oxygen heterocycles: 1,10-dioxa-cyclopenta[a]fluorine and benzo[b]naphtho[2, 1-d]furans via Dötz intramolecular benzannulation. Subhabrata Sen,* Parag Kulkarni, Kailaskumar Borate, Nandini R. Pai, Tetrahedron Letters, 2009, 50, 4128-4131
  • Formal synthesis of piperazinomycin, a novel antifungal antibiotic. Samir Ghosh, A. Sanjeev Kumar, G. N. Mehta, R. Soundararajan* and Subhabrata Sen, ARKIVOC, 2009, vii, 72-78
  • Synthesis of (S, S)-Isodityrosine by Doetz Benzannulation. Anuradha Gupta, Subhabrata Sen, Michael Harmata, and Shon R. Pulley, , 2005, 18, 7422-742
  • Diaryl Ethers Using Fischer Chromium Carbene Mediated Benzannulation. Shon R. Pulley, Subhabrata Sen, Andrei Vorogushin, and Erika Swanson, Organic Letters, 1999, 1, 1721-1723.

Patents

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