Dr. Jayaseelan Murugaiyan

Department of Biotechnology


  1. Proteomics analysis of host-pathogen interactions
  2. Quantitative proteomics analysis of infectious microorganisms
  3. MALDI TOF MS based species identification



Bharathiar University


University of Madras


Bharathidasan University


University of Leipzig


  • 2009-2018 – Group Leader (Proteomics) – Freie Universitaet-Berlin, Germany
  • 2006-2009 – Research student – Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany
  • 2002-2006- Lecturer in Biotechnology – Kongunadu Arts and Science College (Autonomous), Coimbatore, India
  • 2000-2002- Lecturer in Biochemistry – SRM Arts and Science College, Kattankulathur, India
  • 1998-2000-Lecturer in Biochemistry-– Nandhiverman College of Arts and Science, Thellar, India
  • Adhoc Journal reviewer: Scientific report, Applied and Environmental Microbiology (ASM), Frontiers in Medicine, Frontiers in Microbiology, Journal of Agricultural and Food Chemistry (ACS), Cell and Tissue Research, Interdisciplinary Sciences: Computational Life Sciences, Mycopathologia, Current Microbiology, The International Journal of Pharmaceutics, The International Journal of Pure and Applied Analytical Chemistry, Environmental Pollution, Acta histochemica, Alagal Research, Theriogenology, Food control, Future Microbiology, Journal of Basic Microbiology, Proteome Science, Virology Journal, BMC Research Notes, Parasites and vectors, Medical mycology, Pharmaceutical Biology, Innate Immunity , Toxicology and Industrial Health, International Journal of Molecular Sciences, Annals of Laboratory Medicine, Journal of Integrative OMICS, Gigasciences, Veterinaria Italiana, Berliner und Münchener Tierärztliche Wochenschrift, Indian Journal of Biochemistry and Biophysics (IJBB) and PhD thesis of several Universities.
  • Grant application reviewer: National Science Centre, Poland (since 2013)
  • Mentor, DST-INSPIRE program, India

Research Interest

  • Understanding host-pathogen interactions using proteomics techniques such as two dimensional gel electrophoresis (2DE), difference gel Electrophoresis (2D DIGE) and liquid chromatographymass spectrometry (LC-MS) based quantitative proteomics analysis.
  • Identification of immunodominant proteins of infectious micro-organisms using  Serological Proteome Analysis (SERPA) involving real-time samples, 2DE Western blotting and protein identification.
  • Utilisation of MALDI TOF MS in species identification of microorganisms and higher organisms.

Awards & Fellowships

  • June 1999 - March 2000: Indian Council of Medical Research (ICMR) funding to persue M.Sc., Applied Nutrition degree course at the National Institute of Nutrition (NIN), Hyderabad.
  • 2007 & 2010: The welcome Trust/ European Bioinformatics Institute, London, UK to attend advanced course in London


  • ISHAM Medical Phycology : Protothecosis and Chlorellosis Working Group (ISHAM-MPWG) member.
  • The Indian National Science Congress (ISCA), life member
  • Indian Society of Cell Biology (ISCB), life member
  • Society of Biological Chemists (India), life member
  • Nutrition Society of India (NSI), life member


  • MALDI TOF MS profiling-advances in species identification of pests, parasites and vectors, Murugaiyan. J # and Roesler.U., Frontiers in Cellular and Infection Microbiology, 7:184. (2017)
  • Nematode species identification – Current status, challenges and future perspectives for cyathostomins, Kruecken. J, Murugaiyan. J, Kuzmina. T, and von Samson-Himmelstjerna. G, Frontiers in Cellular and Infection Microbiology 7:283. (2017)
  • Mass spectrometry data from label-Free Quantitative Proteomic Analysis of Harmless and Pathogenic Strains of Infectious Microalgae, Prototheca spp.. Murugaiyan. J#., Eravci. M., Weise. C., and Roesler. U., Data in Brief, 17, 320–326. (2017)
  • Isolation of infectious microalga Prototheca wickerhamii from a carp (Cyprinus carpio) – a first confirmed case report of protothecosis in a fish, Jagielsk. T#., Dyląg. M., Roesler. U., and Murugaiyan. J #., Journal of Fish Diseases 40(10):1417-1421 (2017)
  • The efficacy of isolated bacteriophages from pig farms against ESBL/AmpC-producing Escherichia coli from pig and turkey farms. Skaradzinska. A., Śliwka. P., Kuźmińska-Bajor. M., Skaradziński. G., Rząsa. A., Friese. A., Roschanski. N., Murugaiyan. J., and Roesler. U., Frontiers in Microbiology, 8:530. (2017)
  • Label-Free Quantitative Proteomic Analysis of Harmless and Pathogenic Strains of Infectious Microalgae, Prototheca spp.. Murugaiyan. J#., Eravci. M., Weise. C., and Roesler. U., International Journal of Molecular Sciences, 18, 59. (2017)
  • A Comprehensive identification of immunodominant proteins of Brucella abortus and Brucella melitensis using antibodies in the sera from naturally infected hosts, Wareth.G., Eravci. M., Weise. C., Roesler.U., Melzer. F., Sprague. L.D., Neubauer.H., and Murugaiyan. J#., International Journal of Molecular Sciences, 17(5), 659. (2016)
  • Rapid identification of the foodborne pathogen Trichinella spp. by matrix-assisted laser desorption/ionization mass spectrometry, Mayer-Scholl.A., and Murugaiyan.J, Neumann.J, Bahn.P, Reckinger:S, Nöckler.K, PLOSone, 11(3):e0152062 (2016)
  • Well-known surface and extracellular antigens of pathogenic microorganisms among the immunodominant proteins of the infectious microalgae Prototheca zopfii, Irrgang.A., Murugaiyan.J #., Weise.C., Azab. W  and Roesler.U., Frontiers in Cellular and Infection Microbiology 5, 67 (2015)
  • Mass spectrometry data from proteomics-based screening of immunoreactive proteins of fully virulent Brucella strains and sera from naturally infected animals, Wareth.G., Melzer.F., Weise.C., Neubauer.H., Roesler.U., and Murugaiyan.J#., Data in Brief, 4, 587–590. (2015)
  • Assessment of species and antimicrobial resistance among Enterobacteriaceae isolated from mallard duck faeces’, Murugaiyan. J#, Krueger. K., Roesler. U., Weinreich. J., and Schierack.P, Environmental Monitoring and Assessment 187:127, (2015)
  • Proteomics based identification of immunodominant proteins of Brucellae using sera from infected hosts points towards enhanced pathogen survival during the infection.’ Wareth.G., Melzer.F., Weise.C., Neubauer.H., Roesler.U., and Murugaiyan.J#., Biochemical and Biophysical Research Communications. 456(1):202-206 (2015)
  • Identification of antigenic proteins of infectious microalgae (Prototheca spp.) using proteomics approaches, Irrgang.A., Weise.C., Murugaiyan.J #., and Roesler.U., New infections and new microbes, 3, 37-40 (2015)
  • Species differentiation within the Staphylococcus intermedius group using a refined MALDI-TOF MS database, Murugaiyan.J #, Walther.B, Stamm.I, Abouelnaga.Y, Brueggemann-Schwarze. S., Vincze. S., Wieler, L., Luebke-Becker.A., Semmler.T., and Roesler, U., Clinical Microbiology and Infection, 20(10):1007-1015  (2014)
  • Characterization of the native C-reactive protein (cCRP) and the corresponding liver mRNA in dogs, Jasensky.A.K, Bondzio.A, Murugaiyan. J, Siebert. U, Roesler. U, Kohn. B, and Einspanier R., Biochemical and Biophysical Research Communications, 452(3):462-467 (2014)
  • Specific TaqMan® probes for the identification and quantification of lactobacilli in pharmaceuticals. Herbel SR, Nickisch-Rosenegk MV, Kuhn M, Murugaiyan J, Wieler LH., and Guenther S., Journal of Probiotics & Health 2 (115), 2 (2014)
  • Sub-clinical pulmonary pathogenic infection in Camels slaughtered in Cairo, Egypt, Wareth. G, Murugaiyan J, Khater.D.F, and Moustafa.S.A, The Journal of Infection in Developing Countries, 2014, 8(7):909-913 (2014)
  • Analysis of Glossina palpalis gambiensis and Glossina tachinoides from two distant foci in Burkina Faso using MALDI TOF MS, Hoppenheit.A*#, Murugaiyan.J*#, Bauer.B, Clausen.P-H, and Roesler.U, Parasitology Research, 113 (2), 723-726, *co-first/corresponding authors (2014)
  • Species-specific quantification of probiotic lactobacilli in yoghurt by real time PCR, Herbel.S.R, Lauzat.B, von Nickisch-Rosenegk.M, Kuhn.M, Murugaiyan.J, Wieler. LH, and Guenther.G. Journal of Applied Microbiology, 115(6):1402-1410 (2013)
  • Two-dimensional proteome reference map of Prototheca zopfii revealed reduced metabolism and enhanced signal transduction as adaptation to an infectious life style, Murugaiyan.J#, Weise.C., von Bergen.M., and Roesler.U., Proteomics, 13, 2664–2669 (with special commentary in Sept 2013 issue) (2013)
  • Identification of tsetse (Glossina spp.) using Matrix-Assisted Laser Desorption/Ionisation Time of Flight Mass Spectrometry’, Hoppenheit.A*#, Murugaiyan.J*#, Bauer.B, Steuber.S, Clausen.PH, and Roesler.U, PLOS Neglected Tropical diseases 7(7): e2305. *co-first/corresponding authors (2013)
  • Benzo[a]pyrene affects Jurkat T cells in the activated state via the antioxidant response element dependent Nrf2 pathway leading to decreased IL-2 secretion and redirecting glutamine metabolism. Murugaiyan.J, Rockstroh.M, Wagner.J, Baumann.S, Schorsch.K, Trump.S, Lehmann.I, Tomm.J. and von Bergen.M, Toxicology and Applied Pharmacology, 269(3):307-316 (2013)
  • Establishment of MALDI spectra database for rapid identification of achlorophyllous green micro-algae of the genus Prototheca, Murugaiyan.J#, Ahrholdt.J., Kowbel.V., and Roesler.U. Clinical Microbiology and Infection, 18: 461–467 (2012)
  • Genotypical differentiation of worldwide bovine, canine and human clinical Prototheca isolates by means of PCR and MALDI-TOF analysis, Ahrholdt.J, Murugaiyan.J, Straubinger .R.K., Jagielski.T, and Roesler.U.  Medical mycology, 50, 3, 234-243 (2012)
  • Improved MALDI-typing of algae using SOM portraits, Wirth.H, and von Bergen.M, Murugaiyan.J, Roesler.U, Jagielski.T, and Binder.H. Journal of Microbiological Methods, 88(1):83-97 (2012)
  • Integrated serum proteomic and metabolomic profiling reveals association of the complement system with obesity and identifies marker correlating with changes in body weight., Oberbach.A, Blüher.M, Wirth.H, Till.H, Peter.K; Kullnick.Y, Tomm.M.J, Schlichting.N., Rolle-Kampczyk.U, Murugaiyan.J, Binder.H., Dietrich.A., von Bergen.M. Journal of Proteome Research, 2011, 10, 4769–4788 (2011)
  • Identification of harmless and pathogenic algae of the genus Prototheca by MALDI-MS, von Bergen.M, Eidner.A, Schmidt F, Murugaiyan.J, Wirth.H, Binder.H, Maier.T, and Roesler.U. Proteomics - Clinical Applications, 3 (7), 774 – 784 (2009)
  • Autoproteolytic stability of a trypsin from the marine crab Cancer pagurus, Hehemann, J. H., Redecke, L., Murugaiyan, J., von Bergen, M., Betzel, C., and Saborowski, R. Biochemical and Biophysical Research Communications 370 (4), 566-571 (2008)

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