Assistant Professor

Dr. S. Mannathan

Department of Chemistry

Interests

  1. Metal-catalyzed organic transformation reactions
  2. Multicomponent reactions
  3. Asymmetric synthesis.

Education

2004

St. Joseph's College
India
B.Sc

2006

St. Joseph's College
India
M.Sc

2011

National Tsing Hua University
Taiwar
Ph.D.

Experience

  • August 2016 – 2017, Assistant Professor (DST-Inspire faculty) | Research Institute, Department of Chemistry, SRM University, Kattankulathur, Tamilnadu
  • January 2016 – August 2016, Prof. Dr. Kuo-Wei Huang’s group | King Abdullah University of Science and Technology (KAUST), Kingdom of Saudi Arabia.
  • January 2014 – January 2016, Catch-Bio program| Prof. Dr. Adriaan J. Minnaard’s group, University of Groningen, The Netherlands
  • August 2011 – December 2013, National Science Council fellowship (NSC),| Prof. Dr. Chien-Hong Cheng’s group, National Tsing Hua University, Taiwan

Research Interest

  1. TRANSITION METAL COMPLEXES AS CATALYSTS IN ORGANIC REACTIONS
  • Nickel-and cobalt-catalyzed three-component coupling and reductive coupling reactions.
  • Cobalt-catalyzed [3+2] annulation reactions.
  • Nickel and cobalt -catalyzed conjugate addition reactions of organoboronic acid to activated alkenes
  • Palladium-catalyzed reductive arylation
  1. ASSYMETRIC SYNTHESIS
  • Synthesis of enantioselective β-substituted cyclic ketones by chiral cobalt complexes.
  • Synthesis of bicyclic tertiary alcohols and its related asymmetric version via reductive [3+2] cycloaddition reaction by using chiral cobalt complexes

Awards & Fellowships

  • February 2016, DST Inspire Faculty Award, INSA, India.
  • August 2011 – August 2013, National Science Council Fellowship (NSC), Taiwan.
  • 2009 - 2011, Outstanding Foreign Student Award, National Tsing Hua University, Taiwan.

List of Publications

  • The Importance of the Reducing Agent in Direct Reductive Heck Reactions - S. Raoufmoghaddam, S. Mannathan, A. J. Minnaard, J. G. de Vries, B. D. Bruin, J. N. H. Reek, Chem. Cat. Chem. (2017), Accepted; DOI: 10.1002/cctc.201701206
  • Nickel-catalyzed highly chemo- and stereoselective borylative cyclization of 1,6-enynes with bis(pinacolato)diboron - J. C. Hsieh, Y. C. Hong, C. M. Yang, S. Mannathan, C.-H. Cheng, Org. Chem. Front., (2017), Advance Article
  • Enantioselective Intramolecular Reductive Heck Reaction with a Palladium/Monodentate Phosphoramidite Catalyst - S. Mannathan, S. Raoufmoghaddam, J. N. H. Reek, J. G. de Vries, A. J. Minnaard, Chem. Cat. Chem., 9, 551 (2017)
  • Ligand-Controlled Divergent C−H Functionalization of Aldehydes with Enynes by Cobalt Catalysts, R. Santhoshkumar, S. Mannathan, C.-H. Cheng, J. Am. Chem. Soc., 137, 16116-16120 (2015)
  • Palladium(II) Acetate Catalyzed Reductive Heck reaction of Enones; a Practical Approach, S. Mannathan, S. Raoufmoghaddam, J. N. H. Reek, J. G. de Vries, A. J. Minnaard, Chem. Cat. Chem., 7, 3923-3927 (2015)
  • Pd(0)–NHC Catalyzed Reductive Heck Reaction of Enones: A detailed Mechanistic Study, S. Raoufmoghaddam, S. Mannathan, A. J. Minnaard, J. G. de Vries, J. N. H. Reek, Chem. Eur. J. 21, 18811-18820 (2015)
  • Cobalt-catalyzed hydroarylative cyclization of 1,6-enynes with aromatic ketones and esters via C-H activation R. Santhoshkumar, S. Mannathan, C.-H. Cheng, Org. Lett., 16, 4208 – 4211 (2014)
  • Alkene-Assisted Nickel-Catalyzed Regioselective 1,4-Addition of Organoboronic Acid to Dienones: A Direct Route to All-Carbon Quaternary Centers - Y.-C. Hong, P. Gandeepan, S. Mannathan, W.-T. Lee, C.-H. Cheng, Org. Lett., 16, 2806–2809 (2014)
  • [4+2] vs [3+2] Annulations in the Nickel- and Cobalt-Catalyzed Reaction of ortho-Haloimines with Alkynes: Differential Reactivity towards the Synthesis of Isoquinolines and Aminoindenes, S. Mannathan, C.-H. Cheng, J. Chin. Chem. Soc. 61, 59-66 (2014) (Special Issue for the 60th Anniversary of Journal of the Chinese Chemical Society –Invited Mini review)
  • Ene-Carbonyl Reductive Coupling for the Synthesis of 3,3-Disubstituted Phthalide, 3-Hydroxyisoindolin-1-one and 3-Hydroxyoxindole Derivatives, C.-H. Yeh, Y.-C. Lin, S. Mannathan, K. Hung, C.-H. Cheng, Adv. Synth. Catal. 356, 831 – 842 (2014)
  • Nickel-Catalyzed Regio- and Stereoselective Reductive Coupling of Oxa- and Azabicyclic Alkenes with Enones and Electron-Rich Alkynes (also the cover picture for the issue, Adv. Synth. Catal. 356 (10), 2125, (2014), S. Mannathan, C.-H. Cheng, Adv. Synth. Catal. 356, 2239 (2014)
  • Nickel-catalyzed chemo- and stereoselective alkenylative cyclization of 1,6-enynes with alkenylboronic acids- C.-M. Yang, S. Mannathan and C.-H. Cheng, Chem. Eur. J. 19, 12212 – 12216 (2013)
  • Nickel-catalyzed regio- and diastereoselective intermolecular three-component coupling of oxabicyclic alkenes with alkynes and organoboronic acids, S. Mannathan, C.-H. Cheng, Chem.Commun. 49, 1557 (2013)
  • Cobalt(II)-Catalyzed 1,4-addition of Organoboronic Acids to Activated Alkenes: An Application to Highly cis-Stereoselective Synthesis of Aminoindane Carboxylic Acid Derivatives (VIP-Paper)” M.-H. Chen, S. Mannathan, P.-S. Lin and C.-H. Cheng, Chem. Eur. J. 18, 4948 (2012)
  • Regio- and Enantioselective Cobalt-Catalyzed Reductive [3+2] Cycloaddition Reaction of Alkynes with Cyclic Ketones: A Route to Bicyclic Tertiary Alcohols, C.-H. Wei, S. Mannathan, and C.-H. Cheng, Angew. Chem. Int. Ed. 51, 10592 (2012)
  • Synthesis of trans-Disubstituted Alkenes by Cobalt-Catalyzed Reductive Coupling of Terminal Alkynes with Activated Alkenes S. Mannathan and C.-H. Cheng, Chem. Eur. J. 18, 11771 (2012)
  • Enantioselective Synthesis of β-Substituted Cyclic Ketones via Cobalt-Catalyzed Asymmetric Reductive Coupling of Alkynes with Alkenes, C.H. Wei, S. Mannathan and C.-H. Cheng, J. Am. Chem. Soc., 133, 6942 (2011)
  • Cobalt-Catalyzed Regio- and Stereoselective Intermolecular Enyne Coupling: an Efficient Route to 1,3-Diene Derivatives, S. Mannathan and C.-H. Cheng, Chem commun. 46, 1923 (2010)
  • Nickel-Catalyzed Borylative Coupling of Alkynes with Enones and Bis(pinacolato)diboron: A Novel Route to Substituted Alkenylboronates, S. Mannathan, M. Jeganmohan and C.-H. Cheng, - Angew. Chem. Int. Ed. 48, 2192 (2009)
TOP